Assembly of cytochrome c oxidase within the mitochondrion

Accounts of Chemical Research
Heather S Carr, Dennis R Winge

Abstract

Cytochrome c oxidase (CcO) is an oligomeric complex localized within the mitochondrial inner membrane. Assembly of the active oxidase complex requires the coordinate assembly of subunits synthesized in both the cytoplasm and the mitochondrion. In addition, assembly is dependent on the insertion of five types of cofactors, including two hemes, three copper ions, and one Zn, Mg, and Na ion. A series of accessory proteins are critical for synthesis of the heme A cofactor and insertion of the copper ions. This Account will focus on the steps in the coordinate assembly of CcO subunits, the formation of heme A, and the delivery and insertion of copper ions.

References

Sep 1, 1990·Microbiological Reviews·A Tzagoloff, C L Dieckmann
Mar 1, 1988·Molecular & General Genetics : MGG·M Schulze, G Rödel
Mar 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M E PerottiH Swift
Jan 31, 1998·The Journal of Biological Chemistry·J BeersA Tzagoloff
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·K HellR A Stuart
Mar 27, 1998·FEBS Letters·A KirichenkoA Konstantinov
Jul 11, 1998·European Journal of Biochemistry·L G NijtmansC Van den Bogert
May 25, 1999·Protein Science : a Publication of the Protein Society·G BuseM Blüggel
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·S HirotsuT Hakoshima
Jan 5, 2000·The Journal of Biological Chemistry·L HiserJ P Hosler
Sep 6, 2000·The Journal of Biological Chemistry·D HeatonD R Winge
Sep 8, 2001·The Journal of Biological Chemistry·T NittisD R Winge
Jan 10, 2002·Developmental Cell·Luca ScorranoStanley J Korsmeyer
Jan 15, 2002·The Journal of Biological Chemistry·Mario H BarrosAlexander Tzagoloff
Apr 18, 2002·FEBS Letters·Mario H Barros, Alexander Tzagoloff
Aug 13, 2002·The Journal of Biological Chemistry·Marina P NobregaAlexander Tzagoloff

❮ Previous
Next ❯

Citations

Nov 12, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Gnana S SiluvaiNinian J Blackburn
Sep 2, 2008·Nature Chemical Biology·Luciano A AbriataShenlin Wang
May 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lucia BanciPeep Palumaa
Mar 26, 2010·The Journal of Biological Chemistry·Doris BühlerHauke Hennecke
Dec 14, 2011·The Journal of Biological Chemistry·Johannes M Herrmann, Jan Riemer
Jun 15, 2006·Antioxidants & Redox Signaling·Carla M KoehlerEdward P Leverich
Mar 11, 2010·Antioxidants & Redox Signaling·Dionisia P Sideris, Kostas Tokatlidis
Sep 21, 2010·Antioxidants & Redox Signaling·Matthieu DepuydtJean-Francois Collet
Aug 21, 2012·Antioxidants & Redox Signaling·Afroditi Chatzi, Kostas Tokatlidis
Apr 3, 2009·Molecular Biology of the Cell·Martin PresteleMartin Ott
Oct 20, 2009·Human Molecular Genetics·Hua YangEric A Schon
Oct 19, 2010·Journal of Bacteriology·Grzegorz PawlikHans-Georg Koch
Apr 25, 2007·Molecular and Cellular Biology·Heather L FiumeraThomas D Fox
Jan 12, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Jennifer M Zee, D Moira Glerum
Jul 29, 2006·BMC Bioinformatics·Monica ChagoyenAlberto Pascual-Montano
Mar 7, 2013·Genetics·Martha S Cyert, Caroline C Philpott
Dec 26, 2012·Molecular Biology of the Cell·Gavin P McStayAlexander Tzagoloff
Dec 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lucia BanciShenlin Wang
Jun 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lucia BanciShenlin Wang
Mar 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lucia BanciStefano Mangani
Mar 23, 2011·Journal of Aging Research·Raj Kumar, Hani Atamna
Dec 2, 2009·HFSP Journal·Lucia BanciSimone Ciofi-Baffoni
Jan 17, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Fabien PierrelDennis R Winge
Feb 28, 2013·Metallomics : Integrated Biometal Science·Sean P McCormickPaul A Lindahl
Jul 18, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Lucia BanciNigel J Robinson
Sep 30, 2010·The Journal of Cell Biology·David U MickPeter Rehling
Apr 21, 2004·The Journal of Cell Biology·Martin van der LaanArnold J M Driessen
Oct 22, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Estérine EvrardJean Laroche
Jan 23, 2016·Frontiers in Plant Science·Guadalupe Aguirre, Marinus Pilon
Feb 8, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Katerina VeselaMilan Elleder
Oct 4, 2005·Mitochondrion·Oleh Khalimonchuk, Gerhard Rödel
Jul 11, 2006·Chemico-biological Interactions·Rhea MehtaPeter J O'brien
Oct 30, 2016·Biochemistry·José L NeiraBruno Rizzuti
Sep 28, 2005·Acta histochemica·Fabio D'AmicoJames Camakaris
Nov 26, 2008·Biochimica Et Biophysica Acta·David E Davidson, Bruce C Hill
Sep 14, 2007·Structure·Lucia BanciShenlin Wang

❮ Previous
Next ❯

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