Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes

Essays in Biochemistry
Alba Signes, Erika Fernández-Vizarra

Abstract

The assembly of the five oxidative phosphorylation system (OXPHOS) complexes in the inner mitochondrial membrane is an intricate process. The human enzymes comprise core proteins, performing the catalytic activities, and a large number of 'supernumerary' subunits that play essential roles in assembly, regulation and stability. The correct addition of prosthetic groups as well as chaperoning and incorporation of the structural components require a large number of factors, many of which have been found mutated in cases of mitochondrial disease. Nowadays, the mechanisms of assembly for each of the individual complexes are almost completely understood and the knowledge about the assembly factors involved is constantly increasing. On the other hand, it is now well established that complexes I, III and IV interact with each other, forming the so-called respiratory supercomplexes or 'respirasomes', although the pathways that lead to their formation are still not completely clear. This review is a summary of our current knowledge concerning the assembly of complexes I-V and of the supercomplexes.

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S H Ackerman, A Tzagoloff
Dec 12, 1995·Biochimica Et Biophysica Acta·L G NijtmansC van den Bogert
Jun 14, 1996·The Journal of Biological Chemistry·D M GlerumA Tzagoloff
Nov 18, 1997·European Journal of Biochemistry·S Arnold, B Kadenbach
Jun 12, 1998·Journal of Bioenergetics and Biomembranes·S YoshikawaT Tsukihara
Jul 11, 1998·European Journal of Biochemistry·L G NijtmansC Van den Bogert
Dec 5, 1998·American Journal of Human Genetics·V TirantiM Zeviani
Apr 24, 1999·FEBS Letters·B Kadenbach, S Arnold
Jan 5, 2000·The Journal of Biological Chemistry·L HiserJ P Hosler
Feb 22, 2000·The Journal of Biological Chemistry·Z G Wang, S H Ackerman
Mar 30, 2001·The Journal of Biological Chemistry·K S Oyedotun, B D Lemire
Apr 20, 2001·Gene·M HüttemannL I Grossman
Jun 19, 2001·The Journal of Biological Chemistry·Z G WangS H Ackerman
Nov 7, 2001·Journal of Bioenergetics and Biomembranes·U Schulte
Sep 11, 2002·Biochimica Et Biophysica Acta·Stefan KerscherUlrich Brandt
Sep 11, 2002·Biochimica Et Biophysica Acta·Hermann Schägger
Nov 26, 2002·The Journal of Biological Chemistry·Christopher G CarlsonD Moira Glerum
Jan 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Vamsi K MoothaEric S Lander
May 17, 2003·IUBMB Life·Antoni Barrientos
Feb 6, 2004·Journal of Medical Genetics·L De MeirleirR Van Coster
Jul 2, 2004·Human Molecular Genetics·Scot C LearyEric A Shoubridge
Aug 9, 2005·The Biochemical Journal·Lukas StiburekJiri Zeman
Oct 4, 2005·The Journal of Clinical Investigation·Isla OgilvieEric A Shoubridge
Oct 13, 2005·The FEBS Journal·Rutger O VogelLeo G J Nijtmans
Dec 21, 2005·Annals of Neurology·Rosalba CarrozzoHermann Schägger
Apr 25, 2006·Biochimica Et Biophysica Acta·Paul A CobineDennis R Winge
Jun 9, 2006·American Journal of Physiology. Cell Physiology·Flavia FontanesiAntoni Barrientos
Sep 5, 2006·The Journal of Biological Chemistry·Joe CarrollJohn E Walker

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Citations

Nov 8, 2018·Blood·Sarah Ducamp, Mark D Fleming
Jan 25, 2020·Journal of the American Heart Association·Janeesh Plakkal AyyappanJyothi F Nagajyothi
Jan 17, 2020·FEBS Letters·Harrison James Burgin, Matthew McKenzie
Mar 13, 2020·Molecular Genetics & Genomic Medicine·Deyu ChenJianxin Lyu
Apr 8, 2020·Journal of Zhejiang University. Science. B·Fernanda Rafaela JardimMarcos Roberto de Oliveira
Jun 3, 2020·International Journal of Molecular Sciences·Jia Xin TangMonika Oláhová
Jun 4, 2020·International Journal of Molecular Sciences·Cristina PanuzzoDaniela Cilloni
Apr 23, 2020·Molecular & Cellular Proteomics : MCP·Daniella H HockDavid A Stroud
Jul 22, 2018·Essays in Biochemistry·Daniele Ghezzi, Massimo Zeviani
Jun 20, 2019·Nutrients·Ludmila V PuchkovaRoman S Polishchuk
May 14, 2020·F1000Research·Rafael Zardoya
Jun 30, 2019·International Journal of Molecular Sciences·Natalina MoscatelliAlessandra Ferramosca
Jul 9, 2020·Neurology. Genetics·Carola Hedberg-OldforsAnders Oldfors
Sep 26, 2020·Cancers·Chih-Wei ChouTim Hui-Ming Huang
Oct 28, 2020·Antioxidants·Tsu-Kung LinYao-Chung Chuang
Oct 20, 2020·American Journal of Physiology. Renal Physiology·Nehaben A GujaratiSandeep K Mallipattu
Dec 11, 2020·Nucleic Acids Research·Stefano CastellanaTommaso Mazza
Nov 8, 2020·FEBS Letters·Erika Fernandez-Vizarra, Massimo Zeviani
Jan 9, 2021·Biochimica Et Biophysica Acta. Bioenergetics·Karolina Szczepanowska, Aleksandra Trifunovic
Jan 17, 2021·Molecular & Cellular Proteomics : MCP·Daniella H HockDavid A Stroud
Jan 14, 2021·International Journal of Molecular Sciences·Margherita Protasoni, Massimo Zeviani
Feb 1, 2020·Redox Biology·Carolyn M Klinge
Feb 19, 2021·Biochimica Et Biophysica Acta. Bioenergetics·Petra PáleníkováErika Fernández-Vizarra
Feb 26, 2021·Oxidative Medicine and Cellular Longevity·Fengming XuUta Dahmen

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