Assessing auditory processing endophenotypes associated with Schizophrenia in individuals with 22q11.2 deletion syndrome.

Translational Psychiatry
Ana A FranciscoSophie Molholm

Abstract

22q11.2 Deletion Syndrome (22q11.2DS) is the strongest known molecular risk factor for schizophrenia. Brain responses to auditory stimuli have been studied extensively in schizophrenia and described as potential biomarkers of vulnerability to psychosis. We sought to understand whether these responses might aid in differentiating individuals with 22q11.2DS as a function of psychotic symptoms, and ultimately serve as signals of risk for schizophrenia. A duration oddball paradigm and high-density electrophysiology were used to test auditory processing in 26 individuals with 22q11.2DS (13-35 years old, 17 females) with varying degrees of psychotic symptomatology and in 26 age- and sex-matched neurotypical controls (NT). Presentation rate varied across three levels, to examine the effect of increasing demands on memory and the integrity of sensory adaptation. We tested whether N1 and mismatch negativity (MMN), typically reduced in schizophrenia, related to clinical/cognitive measures, and how they were affected by presentation rate. N1 adaptation effects interacted with psychotic symptomatology: Compared to an NT group, individuals with 22q11.2DS but no psychotic symptomatology presented larger adaptation effects, whereas those with...Continue Reading

References

Jan 1, 1992·American Journal of Medical Genetics·R J ShprintzenR W Marion
Jan 1, 1995·The International Journal of Neuroscience·R Näätänen, K Alho
Oct 6, 1999·Biological Psychiatry·A S Bassett, E W Chow
Oct 26, 1999·Archives of General Psychiatry·K C MurphyM J Owen
Dec 1, 1999·Biological Psychiatry·E W ChowA S Bassett
Dec 10, 1999·Psychological Bulletin·R Näätänen, I Winkler
Feb 29, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B OranjeM N Verbaten
May 17, 2000·American Journal of Medical Genetics·A S BassettR Weksberg
May 29, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·P T MichieA V Jablensky
Nov 9, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·S L HansJ Marcus
Dec 15, 2000·Archives of General Psychiatry·D C JavittJ A Lieberman
Feb 24, 2001·Journal of Inherited Metabolic Disease·B K GoodmanG H Thomas
Oct 6, 2001·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·P T Michie
Jan 10, 2002·Journal of Clinical and Experimental Neuropsychology·C E BeardenT D Cannon
Feb 15, 2002·Lancet·Kieran C Murphy
Aug 2, 2002·Archives of General Psychiatry·Dean F SalisburyRobert W McCarley
Oct 29, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Juanita ToddA V Jablensky
Oct 1, 2004·Developmental Neuropsychology·Christina SobinMaria Karayiorgou
Jan 18, 2005·Schizophrenia Research·Anke Brockhaus-DumkeStephan Ruhrmann
Feb 9, 2005·Archives of General Psychiatry·Gregory A Light, David L Braff
Apr 13, 2005·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Renée R Lajiness-O'NeillRebecca Pollack
Mar 7, 2006·Neuroscience Letters·Joel P BishTony J Simon
May 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·Richard PaylorElizabeth Lindsay
Jun 7, 2006·Schizophrenia Research·Eva W C ChowAnne S Bassett
Dec 1, 2006·Schizophrenia Bulletin·Bruce I TuretskyNeal R Swerdlow
Sep 12, 2007·Journal of Intellectual Disability Research : JIDR·B De SmedtA Swillen

❮ Previous
Next ❯

Citations

Aug 28, 2020·Frontiers in Psychiatry·Helena K KimZafiris J Daskalakis
Dec 20, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Liliana Rojas-CharryMichael J Schmeisser
Apr 15, 2021·Orphanet Journal of Rare Diseases·Ana A FranciscoSophie Molholm

❮ Previous
Next ❯

Software Mentioned

MATLAB
stats
EEGLAB
R
lme4

Related Concepts

Related Feeds

22q11 Deletion Syndrome

22q11.2 deletion syndrome, also known as DiGeorge syndrome, is a congenital disorder caused by a partial deletion of chromosome 22. Symptoms include heart defects, poor immune system function, a cleft palate, complications related to low levels of calcium in the blood, and delayed development. Discover the latest research on this disease here.