Assessing biological age: practicality?

Gerontology
C J Bulpitt

Abstract

There are many problems in measuring "biological" age rather than chronological age, not least the necessity of demonstrating that this measure has validity in terms of better predicting mortality or morbidity. This review considers nine problems in measuring biological age and attempts to provide a full or partial solution to these difficulties. The problems presented include the fact that different organs age at different rates; biological age depends on the parameters studied; 'regression dilution bias' may produce misleading results; the validity of the measurement has to be established; the age range for measures has to be agreed; persons affected by accident or disease may or may not be excluded; accidental deaths may have to be excluded from a study of validation; individuals age at different rates at different times, and the fact that longitudinal data are necessary. The solutions suggested include both the presentation of aging profiles including several systems and the provision of summary statistics; adjusting for 'regression dilution bias', and calculating rate of aging from longitudinal studies over different age ranges and in the two sexes separately. It is argued that in this field of research it is well worth co...Continue Reading

Citations

Dec 1, 2000·Asia Pacific Journal of Clinical Nutrition·J D StookeyB M Popkin
May 14, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Fumiyoshi KasagiShoichiro Fujita
May 15, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·René Guéguen
Nov 22, 2005·Southern Medical Journal·Jacqueline GoffauxKarl E Hammermeister
Jun 3, 2014·Journal of Physiological Anthropology·Marina NegashevaElena Godina
Aug 13, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David Andrew GunnKaare Christensen
Oct 4, 2014·Ageing Research Reviews·Correne A DeCarloStuart W S MacDonald
Jun 12, 1999·Journal of the American Geriatrics Society·C J BulpittJ D Cameron

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