Assessing Biological Aggression in Adrenocortical Neoplasia

Surgical Pathology Clinics
Isobel C Mouat, Thomas J Giordano

Abstract

Pathologists are highly skilled at the evaluation of adrenal neoplasms. Occasional adrenocortical tumors can be diagnostically challenging and supplementary tools can assist in these cases. Histologic and molecular studies support a model that includes 2 broad classes of adrenocortical carcinoma with distinct somatic genetic alterations and clinical outcomes. Pathologists should endeavor to grade adrenocortical carcinomas to assign each case into one of these 2 classes. Mitotic grading by mitotic counting and Ki-67 immunohistochemistry represent the most practicable and informative methods currently available.

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Citations

Mar 16, 2018·Endocrine Pathology·Ozgur MeteMarco Volante
Dec 20, 2015·The American Journal of Surgical Pathology·Thomas G PapathomasRonald R de Krijger

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