Assessing changes over time in temporal lobectomy: outcome by scoring seizure frequency

Epilepsy Research
E L SoP C O'Brien

Abstract

Current methods of evaluating seizure outcome after anterior temporal lobectomy (ATL) have major limitations. We evaluated the usefulness of a recently proposed system in our study of the stability of seizure frequency after ATL in 184 patients with intractable epilepsy. Data collection by chart review was supplemented by an intensive program of follow-up by our survey research center through correspondence or phone calls according to a protocol approved by our Institutional Review Board. Seizure frequency during each 12-month period after ATL was scored for each patient. The only statistically significant change in seizure frequency scores during follow-up was between the third and the fourth years (means of 2.61 and 2.11; P < 0.045). Further assessment showed that the change was most likely due to an increase in the proportion of patients who achieved a score of 0 when they successfully stopped taking antiepileptic medications (9.1% in the third year and 22.5% in the fourth year; P < 0.05). There was no statistically significant difference between follow-up years in the proportion of patients achieving excellent outcome (i.e. scores of 0-4). Outcome remained unchanged when follow-up at each year was confined to the same patie...Continue Reading

References

Sep 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A RougierF Cohadon
Apr 1, 1991·Epilepsy Research·G A BakerD W Chadwick
Jan 1, 1984·Magnetic Resonance Imaging·H D SostmanR H Mattson
Jan 1, 1984·Annals of Neurology·E A AugustineS S Spencer
May 1, 1995·Neurology·M R SperlingM J O'Connor
Aug 25, 2009·Epilepsy Research·J W PanS S Spencer

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Citations

Dec 4, 2003·Epilepsy Research·Dieter Schmidt, Wolfgang Löscher
May 20, 2008·Lancet Neurology·Susan Spencer, Linda Huh
Aug 4, 2001·The New England Journal of Medicine·S WiebeUNKNOWN Effectiveness and Efficiency of Surgery for Temporal Lobe Epilepsy Study Group
Jul 17, 2010·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Chaturbhuj Rathore, Kurupath Radhakrishnan
Jul 18, 2000·Epilepsia·R K MosewichP C O'Brien
Aug 30, 2000·Epilepsia·M B Rao, K Radhakrishnan
Dec 21, 2007·Epilepsia·Florise A C P Lambrechtsen, Jeffrey R Buchhalter
Oct 25, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·L JutilaA Ylinen
Nov 26, 2008·Journal of Neurosurgery·Alaa Eldin ElsharkawyAlois Ebner
Nov 27, 2002·Journal of Neurosurgery·Hans ClusmannChristian E Elger
Apr 15, 2003·Journal of Neurosurgery·H Gregor WieserYasuhiro Yonekawa
Apr 2, 2008·Journal of Neurosurgery·Alaa Eldin ElsharkawyAlois Ebner
Apr 24, 2007·Epilepsy Research·Alcibiades J RodriguezElson L So
Dec 2, 2005·Clinical Neurology and Neurosurgery·Ashalatha RadhakrishnanKurupath Radhakrishnan
Jul 26, 2011·Epilepsy Research·Neeraj N BahetiKurupath Radhakrishnan
Apr 12, 2008·Seizure : the Journal of the British Epilepsy Association·F Irsel TezerSerap Saygi
Apr 5, 2014·Journal of the Neurological Sciences·B V Savitr SastriP Satishchandra
Jan 3, 2015·Revue neurologique·B MathonS Clemenceau
Jul 30, 2004·Brain : a Journal of Neurology·R P CarneM J Cook
Dec 25, 2008·Neurologia Medico-chirurgica·Kouzo MoritakeNobuo Hashimoto
Jun 22, 2018·Neurology·Chaturbhuj RathoreKurupath Radhakrishnan
Dec 29, 2020·Epilepsy & Behavior : E&B·Yew Li DangCharles B Malpas
Sep 23, 2020·Seizure : the Journal of the British Epilepsy Association·Udit U SarafSanjeev V Thomas

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