Assessing chemical constituents of Mimosa caesalpiniifolia stem bark: possible bioactive components accountable for the cytotoxic effect of M. caesalpiniifolia on human tumour cell lines

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Nayana Bruna Nery MonçãoAntonia Maria das Graças Lopes Citó

Abstract

Mimosa caesalpiniifolia is a native plant of the Brazilian northeast, and few studies have investigated its chemical composition and biological significance. This work describes the identification of the first chemical constituents in the ethanolic extract and fractions of M. caesalpiniifolia stem bark based on NMR, GC-qMS and HRMS analyses, as well as an assessment of their cytotoxic activity. GC-qMS analysis showed fatty acid derivatives, triterpenes and steroid substances and confirmed the identity of the chemical compounds isolated from the hexane fraction. Metabolite biodiversity in M. caesalpiniifolia stem bark revealed the differentiated accumulation of pentacyclic triterpenic acids, with a high content of betulinic acid and minor amounts of 3-oxo and 3β-acetoxy derivatives. Bioactive analysis based on total phenolic and flavonoid content showed a high amount of these compounds in the ethanolic extract, and ESI-(-)-LTQ-Orbitrap-MS identified caffeoyl hexose at high intensity, as well as the presence of phenolic acids and flavonoids. Furthermore, the evaluation of the ethanolic extract and fractions, including betulinic acid, against colon (HCT-116), ovarian (OVCAR-8) and glioblastoma (SF-295) tumour cell lines showed tha...Continue Reading

References

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Citations

Sep 15, 2016·Anais Da Academia Brasileira De Ciências·Francisco R S CarvalhoAna Paula Peron
Aug 17, 2017·Anais Da Academia Brasileira De Ciências·Mauricio M VictorAna J Araújo
Jun 23, 2020·Journal of Toxicology and Environmental Health. Part a·Jurandy do Nascimento SilvaPaulo Michel Pinheiro Ferreira
Sep 13, 2020·Analytical and Bioanalytical Chemistry·Giulia Carolina LodiFrancesca Caterina Izzo
Oct 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lin-Yang ChengJih-Jung Chen
Jul 25, 2021·International Journal of Molecular Sciences·Ismat MajeedLuigi Geo Marceanu
Dec 1, 2021·Natural Product Research·Claudie Fokou KenmogneLéon Azefack Tapondjou

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Methods Mentioned

BETA
column chromatography
Assay

Software Mentioned

GraphPad Prism
Origin
GraphPad

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