Assessing cognitive dysfunction in Parkinson's disease: An online tool to detect visuo-perceptual deficits.

Movement Disorders : Official Journal of the Movement Disorder Society
Rimona S WeilHuw R Morris

Abstract

People with Parkinson's disease (PD) who develop visuo-perceptual deficits are at higher risk of dementia, but we lack tests that detect subtle visuo-perceptual deficits and can be performed by untrained personnel. Hallucinations are associated with cognitive impairment and typically involve perception of complex objects. Changes in object perception may therefore be a sensitive marker of visuo-perceptual deficits in PD. We developed an online platform to test visuo-perceptual function. We hypothesised that (1) visuo-perceptual deficits in PD could be detected using online tests, (2) object perception would be preferentially affected, and (3) these deficits would be caused by changes in perception rather than response bias. We assessed 91 people with PD and 275 controls. Performance was compared using classical frequentist statistics. We then fitted a hierarchical Bayesian signal detection theory model to a subset of tasks. People with PD were worse than controls at object recognition, showing no deficits in other visuo-perceptual tests. Specifically, they were worse at identifying skewed images (P < .0001); at detecting hidden objects (P = .0039); at identifying objects in peripheral vision (P < .0001); and at detecting biolog...Continue Reading

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Oct 5, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Rimona S WeilHuw R Morris

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Citations

Oct 23, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·I V LitvinenkoD S Maltsev
Oct 22, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Elena PretegianiLance M Optican
Jan 10, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Angeliki ZarkaliRimona S Weil

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Software Mentioned

JAGS
JAGS ( Just Another Gibbs Sampler )
Vision Object
R
MATLAB

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