Assessing cognitive function in clinical trials of schizophrenia.

Neuroscience and Biobehavioral Reviews
Jennifer H BarnettAndrew D Blackwell

Abstract

Cognitive dysfunction in schizophrenia is an important target for novel therapies. Effectively measuring the cognitive effects of compounds in clinical trials of schizophrenia could be a major barrier to drug development. The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) programme produced a consensus cognitive battery which is now widely used, however alternative assessments have advantages and disadvantages when compared with MATRICS. The Cambridge Neuropsychological Test Automated Battery (CANTAB) is a computerised assessment developed from animal behaviour paradigms and human neuropsychology. We review the utility of CANTAB according to MATRICS and CNTRICS recommendations. CANTAB tests have been used in more than 60 studies of psychotic disorders. Their neural bases are well understood through patient and neuroimaging studies and directly equivalent tests in rodents and non-human primates. The tests' sensitivity to pharmacological manipulation is well established. Future studies should collect more data regarding psychometric properties in patients over short time periods, and should continue to study the tests' relationships to functional outcomes. Computerised cognitive assessment may ...Continue Reading

References

Aug 1, 1991·Psychological Medicine·T ShalliceC D Frith
Jan 1, 1990·Neuropsychologia·A M OwenT W Robbins
Jun 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·B SahakianD Warburton
Sep 19, 1987·British Medical Journal·R M Murray, S W Lewis
Oct 17, 1987·British Medical Journal·J L Waddington, H A Youssef
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Jun 25, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T Shallice
Jun 25, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M Mishkin
Jun 1, 1982·Pharmacology, Biochemistry, and Behavior·P R GoddingW W Beatty
Feb 1, 1994·Archives of General Psychiatry·A J SaykinR C Gur
Sep 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·L RifkinR Murray
Sep 1, 1995·Schizophrenia Research·S Sevy, M Davidson
Feb 1, 1996·The European Journal of Neuroscience·A M OwenA C Evans
Jun 1, 1996·Neuropsychologia·S C BakerT W Robbins
May 3, 1997·Schizophrenia Research·D I VelliganA L Miller
Jul 31, 1997·Nature·B DevlinK Roeder
Apr 29, 1998·Journal of Clinical Psychopharmacology·T Sharma, D Mockler
Jul 23, 1998·Neuropsychology·R W Heinrichs, K K Zakzanis
Aug 4, 1999·Brain : a Journal of Neurology·S RahmanT W Robbins
Aug 6, 1999·Archives of General Psychiatry·S MohamedN Andreasen
Feb 10, 2000·Brain Research. Cognitive Brain Research·T H RammsayerD Groh
Mar 22, 2000·The Clinical Neuropsychologist·M R BassoJ M Lang
Mar 30, 2000·The American Journal of Psychiatry·R M BilderJ A Lieberman
Oct 18, 2000·The British Journal of Clinical Psychology·A J RussellR M Murray
Feb 24, 2001·Journal of Abnormal Psychology·W S KremenM T Tsuang

❮ Previous
Next ❯

Citations

Dec 8, 2011·Psychopharmacology·Barbara LangenNorbert Hoefgen
Jul 4, 2013·Psychopharmacology·Abbie PringleCatherine J Harmer
Dec 4, 2012·Nature Neuroscience·Jess NithianantharajahSeth G N Grant
Dec 2, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francois GastambideMark D Tricklebank
Sep 21, 2013·Nature Protocols·Alexa E HornerTimothy J Bussey
May 20, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dawn M EagleTrevor W Robbins
Dec 12, 2013·Biomarkers in Medicine·Brett A EnglishLarry Ereshefsky
Oct 5, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marcelo P CobaSeth G N Grant
Aug 1, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hiroyuki KoikeHirofumi Morishita
Oct 16, 2012·Neuroscience and Biobehavioral Reviews·Jared W YoungDaniel M Hutcheson
Feb 1, 2011·Journal of Neuroscience Methods·Jesse S RodriguezMark J Nijland
Jul 24, 2015·Psychopharmacology·M Hvoslef-EideT J Bussey
Jul 23, 2011·Neuroscience and Biobehavioral Reviews·Paul J KennedyJohn F Cryan
Jul 15, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stamatina TzanoulinouCarmen Sandi
Aug 5, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Barbara J SahakianPeter B Jones
Aug 22, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Christopher G AhnAllenJennifer W Tidey
Jul 3, 2013·Biological Psychiatry·Diego ScheggiaFrancesco Papaleo
Mar 15, 2011·The International Journal of Neuropsychopharmacology·Ahmed D Mohamed, Barbara J Sahakian
May 15, 2016·Journal of Affective Disorders·Isabelle E BauerJair C Soares
Jul 19, 2016·International Journal of Geriatric Psychiatry·Sanjeev KumarTarek K Rajji
Oct 30, 2016·Neuroscience and Biobehavioral Reviews·Jonas FizetHélène Meunier
Dec 18, 2014·Journal of Psychopharmacology·J W Young, M A Geyer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here