Assessing efficacy in early-phase cancer prevention clinical trials: the case of ki-67 in the lung.

Cancer Prevention Research
Eva Szabo

Abstract

This perspective on Kim et al. (beginning on p. 148 in this issue of the journal) examines the value of the Ki-67 proliferation index as a surrogate end point in early-phase clinical lung cancer prevention trials. The clinical trial of Kim et al. shows an effect of the cyclooxygenase-2-selective inhibitor celecoxib at a high dose on Ki-67 expression in the normal bronchial epithelia of current and former smokers. The critical issue of how these data can be used to further drug development is discussed.

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Citations

Jul 8, 2011·Cancer Prevention Research·Jenny T MaoDavid Elashoff
Sep 8, 2010·Seminars in Oncology·Eva Szabo
Jul 8, 2011·Cancer Prevention Research·Fadlo R Khuri

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