Assessing familial aggregation of paratuberculosis in beef cattle of unknown pedigree

Preventive Veterinary Medicine
Jason B OsterstockAllen J Roussel

Abstract

The objective of this study was to assess genetic similarity of beef cattle using microsatellite markers and to use this information to describe familial aggregation of paratuberculosis test results in Texas beef cattle. Paratuberculosis testing was performed on 2622 adult beef cattle using two commercially available serum ELISAs and radiometric fecal culture. Pedigree records were collected for registered purebred herds and herds with sufficiently detailed production records to identify parent-offspring pairs. Cases were defined as cattle with at least one positive paratuberculosis test result. Three controls were matched by herd of residence for each case. All parent-offspring pairs, cases, and controls were genotyped for 12 microsatellites. Bayesian analysis of allele frequency data was used to describe population substructure and assign individual cattle into groups of genetically similar cattle. The proportion of known parent-offspring pairs assigned to the same cluster was used to assess the validity of the approach to identify familial structure. Conditional logistic regression was used to describe the association between cluster assignment and paratuberculosis test-status matched by herd. Nine clusters of genetically si...Continue Reading

References

Sep 8, 1979·The Veterinary Record·R Sellwood
Jul 1, 1997·Preventive Veterinary Medicine·J G Thorne, L E Hardin
Mar 11, 1998·Journal of Dairy Science·J R Stabel
Jul 29, 1999·Preventive Veterinary Medicine·S L OttB A Wagner
Jun 3, 2000·Genetics·J K PritchardP Donnelly
Aug 24, 2001·Journal of the American Veterinary Medical Association·D A DargatzS J Wells
Dec 21, 2002·Science·Noah A RosenbergMarcus W Feldman
Feb 13, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·B B HillK V Brock
Oct 11, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Mel PenceC Carter Black
Mar 22, 2005·Journal of the American Veterinary Medical Association·Allen J RousselJames A Thompson
Jun 9, 2005·Clinical and Diagnostic Laboratory Immunology·Michael T CollinsRobert H Whitlock
Jul 23, 2005·Australian Veterinary Journal·L A ReddacliffR J Whittington
Dec 29, 2005·Journal of the American Veterinary Medical Association·Jason E LombardBruce A Wagner
Apr 12, 2006·Journal of Dairy Science·M G GondaB W Kirkpatrick
Oct 14, 2006·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Jason E LombardBrian J McCluskey
Mar 17, 2007·Journal of the American Veterinary Medical Association·Allen J RousselMichael T Collins
Mar 17, 2007·Journal of the American Veterinary Medical Association·Jason B OsterstockAllen J Roussel
Dec 7, 2007·Veterinary Microbiology·Jason B OsterstockAllen J Roussel

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Citations

Oct 26, 2011·The Veterinary Clinics of North America. Food Animal Practice·Raymond W Sweeney

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