PMID: 2498954Jan 1, 1989Paper

Assessing individual differences in ethanol preference using a cumulative dosing procedure

Psychopharmacology
H deWitC E Johanson

Abstract

Preference for ethanol versus a placebo was assessed in 12 normal volunteers usina a cumulative dosing preference test. The test consisted of four sampling sessions followed by three choice sessions. During the sampling sessions subjects received either five cumulating oral doses of ethanol (0.1 g/kg per dose) or equal volumes of placebo, at 15-min intervals. Subjective and observer-rated drug effects, psychomotor performance, drug liking ratings, and breath ethanol levels were measured at regular intervals. During choice sessions, subjects first chose which of the two substances (drug or placebo) they wished to take and ingested one unit dose. Then, at 15-min intervals throughout the session, they could ingest up to ten additional unit doses of the same substance (i.e., up to 1.1 g/kg ethanol). On average, the subjects chose the ethanol-containing beverage on 75% of the choice sessions, and they self-administered a mean total dose of 0.8 g/kg per session. Subjects varied in the amount of ethanol ingested on choice sessions, and the amount they chose was related to their subjective responses to the drug during sampling. Subjects who chose the most ethanol, whereas the subjects who chose ethanol less frequently and ingested lowe...Continue Reading

References

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Citations

Dec 1, 1994·Psychopharmacology·K A PerkinsR L Stiller
Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Diana J Walker, James P Zacny
Sep 22, 2005·Experimental and Clinical Psychopharmacology·Frances K McSweeneyBenjamin P Kowal
Dec 1, 1991·British Journal of Addiction·H De Wit
Feb 1, 1990·Alcoholism, Clinical and Experimental Research·H de Wit, S G McCracken
Jun 1, 1990·Alcoholism, Clinical and Experimental Research·H de WitM Cooper
Jan 12, 1999·Alcoholism, Clinical and Experimental Research·L Holdstock, H de Wit
May 11, 1999·Alcoholism, Clinical and Experimental Research·L Holdstock, H de Wit
Jul 11, 2000·Alcoholism, Clinical and Experimental Research·L HoldstockH de Wit
May 1, 2001·Alcoholism, Clinical and Experimental Research·L Holdstock, H de Wit
Mar 30, 2002·Alcoholism, Clinical and Experimental Research·Ola BlomqvistHenry R Kranzler
Oct 1, 1994·The International Journal of the Addictions·H de Wit, B Bodker
Jan 5, 2016·Alcoholism, Clinical and Experimental Research·Lara A RayDaniel J O Roche
May 18, 2005·Alcoholism, Clinical and Experimental Research·Frances H Gabbay
May 27, 2003·Alcoholism, Clinical and Experimental Research·Henry Chi, Harriet de Wit
Apr 29, 2004·Alcoholism, Clinical and Experimental Research·Kim FrommeDavid Goldman
Oct 9, 2008·Alcoholism, Clinical and Experimental Research·Suzette M Evans, Adam Bisaga
Feb 3, 2011·British Journal of Clinical Pharmacology·Remco W M ZoethoutJoop M A van Gerven
Jul 19, 2011·Alcoholism, Clinical and Experimental Research·Emma ChildsHarriet de Wit
May 18, 2011·Alcoholism, Clinical and Experimental Research·Anna H V Söderpalm Gordh, Bo Söderpalm
Jan 1, 1994·Journal of Substance Abuse·N G CascellaK M Kumor
Oct 19, 2004·Drug and Alcohol Dependence·Diana J WalkerJames P Zacny
Nov 22, 2005·Drug and Alcohol Dependence·Adam Bisaga, Suzette M Evans
May 27, 2015·Alcoholism, Clinical and Experimental Research·Spencer BujarskiLara A Ray
May 8, 2015·Pharmacogenomics·Daniel Jo Roche, Lara A Ray
Jun 9, 2016·Behaviour Research and Therapy·Spencer Bujarski, Lara A Ray
Jun 14, 2012·Journal of the Experimental Analysis of Behavior·John M RollMatt Torrington
Nov 18, 2020·Alcoholism, Clinical and Experimental Research·Jingfei LiHarriet de Wit

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