PMID: 9532416Apr 9, 1998Paper

Assessing microcirculation in familial dysautonomia by laser Doppler flowmeter

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
M WeiserF B Axelrod

Abstract

Microcirculatory vasomotor responses to an alpha-adrenergic agonist and an antagonist were assessed in 11 familial dysautonomia and nine control subjects by laser Doppler flowmetry. Using two iontophoresis machines, blood flow in the midclavicular areas was continuously monitored by two channel laser Doppler flowmeter. Simultaneously, the alpha-antagonist (0.5 mM phentolamine hydrochloride) and a control solution (0.9% saline) were iontophoresed at 200 microA for 15 min. The alpha-agonist (0.5 mM norepinephrine bitartrate) was then iontophoresed (20 microA) to both pretreated areas for progressively longer pulses separated by 3-min observation intervals (15, 30, 60, 90, 120 s). The familial dysautonomia subject group had higher mean baseline perfusion with widely fluctuating baselines, especially on the phentolamine pretreated side (P = 0.03). Saline iontophoresis significantly increased perfusion in the control group, but not in the familial dysautonomia group (ANOVA: P = 0.02 and 0.15, respectively). There was > 100% increase in flow by the end of the saline observation period in seven of nine controls, but in only three of 11 familial dysautonomia subjects. Phentolamine iontophoresis differentiated familial dysautonomia subj...Continue Reading

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Citations

Apr 18, 2002·Journal of the Neurological Sciences·M J HilzB Stemper
Aug 20, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·A BickelM J Hilz
Mar 4, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mido M HijaziTimo Siepmann
Sep 27, 2003·European Journal of Clinical Investigation·H MartholM J Hilz
Sep 1, 2017·Frontiers in Neurology·Marie Luise KubaschTimo Siepmann
Jul 13, 2000·Neurology·F B AxelrodE L Kramer

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