Assessing motor, visual and language function using a single 5-minute fMRI paradigm: three birds with one stone

Brain Imaging and Behavior
Simona FioriMarko Wilke

Abstract

Clinical functional Magnetic Resonance Imaging (fMRI) requires inferences on localization of major brain functions at the individual subject level. We hypothesized that a single "triple use" task would satisfy sensitivity and reliability requirements for successfully assessing the motor, visual and language domain in this context. This was tested here by the application in a group of healthy adults, assessing sensitivity and reliability at the individual subject level, separately for each domain.Our "triple use" task consisted of 2 conditions (condition 1, assessing motor and visual domain, and condition 2, assessing the language domain), serving mutually as active/control. We included 20 healthy adult subjects. Random effect analyses showed activation in primary motor, visual and language regions, as expected. Less expected regions were activated both for the motor and visual domains. Further, reliability of primary activation patterns was very high across individual subjects, with activation seen in 70-100% of subjects in primary motor, visual, and left-lateralized language regions.These findings suggest the "triple use" task to be reliable at the individual subject's level to assess motor, visual and language domains in the ...Continue Reading

References

Dec 1, 1996·NeuroImage·K R ThulbornJ A Sweeney
Sep 30, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J M OjaP C van Zijl
Feb 5, 2000·Nature·P BelinB Pike
Feb 13, 2001·The European Journal of Neuroscience·G BuccinoH J Freund
Apr 17, 2001·NeuroImage·J L AnderssonK Friston
Apr 27, 2002·Journal of Neurophysiology·M F S RushworthP K Sipila
Sep 24, 2002·Brain : a Journal of Neurology·Martin StaudtIngeborg Krägeloh-Mann
Feb 21, 2003·Journal of Child Neurology·Anna Weber ByarsElena Plante
Nov 5, 2003·Neuropediatrics·M WilkeW S Ball
Nov 6, 2003·Statistical Methods in Medical Research·Thomas Nichols, Satoru Hayasaka
Feb 26, 2004·Journal of Vascular Nursing : Official Publication of the Society for Peripheral Vascular Nursing·Gail Ann DeLuca Havens
Oct 27, 2004·Neurology·W D GaillardW H Theodore
Nov 25, 2004·Annals of Neurology·Martin StaudtIngeborg Krägeloh-Mann
Feb 11, 2005·Cerebral Cortex·Juha SilvantoVincent Walsh
Oct 4, 2005·Journal of Cognitive Neuroscience·Raffaella I RumiatiGereon R Fink
Jan 24, 2006·Brain and Cognition·Edson Amaro, Gareth J Barker
Jan 24, 2006·Neuropediatrics·V MallJ Spreer
Feb 21, 2006·NeuroImage·Alexander DrobyshevskyWalter Schneider
May 3, 2006·NeuroImage·Marko WilkeIngeborg Krägeloh-Mann
Oct 27, 2006·NeuroImage·Prasanna R KarunanayakaElena Plante
Jan 24, 2007·NeuroImage·Bertrand ThirionJean-Baptiste Poline
Mar 28, 2007·Journal of Neuroscience Methods·Marko Wilke, Karen Lidzba
May 23, 2007·Pediatric Research·Andrea GuzzettaGiovanni Cioni
Jul 19, 2008·Human Brain Mapping·Weihong YuanScott K Holland
Oct 10, 2008·Nature Reviews. Neuroscience·Parashkev NachevMasud Husain
Mar 11, 2009·IEEE Transactions on Bio-medical Engineering·Lejian HuangThomas M Talavage
Mar 24, 2009·Journal of Magnetic Resonance Imaging : JMRI·Jennifer J VannestScott K Holland
Jun 6, 2009·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Linda J LanyonJason J S Barton
Sep 22, 2009·Brain Research·Preston P Thakral, Scott D Slotnick
Feb 26, 2010·Trends in Cognitive Sciences·Okihide Hikosaka, Masaki Isoda
May 25, 2010·Human Brain Mapping·Jessica A ChurchBradley L Schlaggar
Jun 12, 2010·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Marko WilkeIngeborg Krägeloh-Mann
Dec 25, 2010·Human Brain Mapping·Marko WilkeIngeborg Krägeloh-Mann
Jan 25, 2011·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Maryam S KhorramiFeroze B Mohamed
Apr 1, 2011·Brain and Language·Karen LidzbaMarko Wilke
Jun 17, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jane B AllendorferJerzy P Szaflarski

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Citations

Nov 28, 2018·Annals of Clinical and Translational Neurology·Marko WilkeIngeborg Krägeloh-Mann
May 16, 2020·Frontiers in Human Neuroscience·Mariam Al HarrachMickael Dinomais
Jun 2, 2020·Neurosurgery Clinics of North America·Niels Alexander FoitNeda Bernasconi

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BETA
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