Assessing Natural Product-Drug Interactions: An End-to-End Safety Framework

Regulatory Toxicology and Pharmacology : RTP
Amy L RoeJames C Griffiths

Abstract

The use of natural products (NPs), including herbal medicines and other dietary supplements, by North Americans continues to increase across all age groups. This population has access to conventional medications, with significant polypharmacy observed in older adults. Thus, the safety of the interactions between multi-ingredient NPs and drugs is a topic of paramount importance. Considerations such as history of safe use, literature data from animal toxicity and human clinical studies, and NP constituent characterization would provide guidance on whether to assess NP-drug interactions experimentally. The literature is replete with reports of various NP extracts and constituents as potent inhibitors of drug metabolizing enzymes, and transporters. However, without standard methods for NP characterization or in vitro testing, extrapolating these reports to clinically-relevant NP-drug interactions is difficult. This lack of a clear definition of risk precludes clinicians and consumers from making informed decisions about the safety of taking NPs with conventional medications. A framework is needed that describes an integrated robust approach for assessing NP-drug interactions; and, translation of the data into formulation alteration...Continue Reading

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Citations

Jun 9, 2018·Clinical Pharmacology and Therapeutics·Amy L RoeCatherine Mahony
May 11, 2018·Clinical Pharmacology and Therapeutics·Cynthia V RiderSuramya Waidyanatha
Jul 13, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jonathan P JacksonAmy L Roe
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Dec 20, 2020·Expert Opinion on Drug Metabolism & Toxicology·Baron Bechtold, John Clarke
Nov 12, 2021·Recent Patents on Anti-cancer Drug Discovery·Lu ChenWanyi Chen

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