Assessing ocular bulbar redness: a comparison of methods

Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)
Laura Elizabeth DownieAlgis J Vingrys

Abstract

We consider whether quantification of ocular bulbar redness, using image processing of relative Red-channel activity (Red-value), can be applied to a clinical sample and how this approach compares to an automated bulbar redness grading technique (Oculus Keratograph 5M, R-scan). Red-values from dry eye patients (n = 25) were determined using image processing of digital photographs over the nasal bulbar conjunctiva. Red-values were compared with subjective grades from six clinicians who graded the images using the IER scale. We considered the level of agreement between the Red-value and automated bulbar redness scores from the commercial instrument (R-scan). Scoring variability for each technique was assessed using the geometric coefficient of variation (gCoV, %). Agreement between techniques was considered with Bland-Altman analyses. Red-values showed a strong linear relationship (R(2) = 0.99) to the R-scan. The Red-value had least variability (gCoV = 0.97%, 95% CI: 0.76-1.35%). The IER grade showed a linear relationship with Red-value (R(2) = 0.99), bound by a floor effect; it did not discriminate changes in redness below a threshold of 1.75 units (Red-value = 33.0%), after which it paralleled the redness returned by the R-scan...Continue Reading

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Citations

Jan 26, 2017·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Etty BittonWalter Wittich
Sep 3, 2016·Statistical Methods in Medical Research·Andrew Carkeet, Yee Teng Goh
Sep 10, 2020·Scientific Reports·Wan-Hua ChoMing-Tse Kuo
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Apr 24, 2019·International Journal of Molecular Sciences·Ming-Tse KuoChia-Yi Tseng
Jan 7, 2021·International Journal of Molecular Sciences·Ming-Tse KuoYu-Ting Huang
Feb 4, 2021·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Marc-Matthias SchulzeMichelle Senchyna
Oct 15, 2020·The Ocular Surface·Cristian Talens-EstarellesSantiago García-Lázaro

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