Assessing Outcomes of Patients Treated With Re-Irradiation Utilizing Proton Pencil-Beam Scanning for Primary or Recurrent Malignancies of the Esophagus and Gastroesophageal Junction

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Cristina M DeCesarisJason K Molitoris

Abstract

Re-irradiation (re-RT) for locoregionally recurrent esophageal and gastroesophageal junction (GEJ) cancer and de novo esophageal + GEJ cancer arising in-field after a course of prior radiation poses considerable treatment challenges given the sensitivity of surrounding organs at risk (OARs). Guidelines for treatment of this presentation are not well established. Pencil-beam scanning (PBS) proton therapy has the ability to decrease radiation dose to OARs relative to photon plans. We present the first published series to date of re-RT with PBS for esophageal + GEJ malignancies and hypothesize that re-RT with proton PBS will be feasible and improve the safety profile of re-RT for this cohort of patients. Consecutive esophageal + GEJ cancers treated with PBS re-RT within a single institution were analyzed. Comparative volumetric-modulated arc therapy photon plans were generated. A total of 17 patients were included for analysis. At a median follow-up of 11.6 months, 1-year local control was 75.3% and overall survival was 68.9%. There were five (27.8%) grade 3 or higher late toxicities. When matched for clinical target volume coverage, proton PBS plans delivered significantly lower doses to the spinal cord, lungs, liver, and heart (...Continue Reading

References

Jan 10, 2002·The Journal of Thoracic and Cardiovascular Surgery·Stephen G SwisherGarrett L Walsh
Jun 17, 2008·International Journal of Radiation Oncology, Biology, Physics·Erik P SulmanAdam S Garden
Aug 5, 2009·Journal of Surgical Oncology·Hiroshi MiyataYuichiro Doki
Aug 28, 2012·The Annals of Thoracic Surgery·Jenifer L MarksStephen G Swisher
Jan 25, 2013·Radiation Oncology Journal·Young Suk KimWoong Sub Koom
May 27, 2014·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Patricia SponsellerShilpen Patel
Dec 25, 2015·Journal of Applied Clinical Medical Physics·Liyong LinCharles B Simone
Feb 6, 2016·International Journal of Radiation Oncology, Biology, Physics·Annemarie FernandesJohn P Plastaras
Apr 17, 2016·International Journal of Radiation Oncology, Biology, Physics·Paul B RomesserNancy Y Lee
Jun 2, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Nils H NicolayKatja Lindel
Oct 30, 2016·International Journal of Radiation Oncology, Biology, Physics·Mark W McDonaldMichael G Moore
Nov 9, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hann-Hsiang ChaoJohn P Plastaras
Jul 9, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mian XiSteven H Lin
Jul 13, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·David M GuttmannCharles B Simone
Sep 18, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yutaka ShiraishiSteven H Lin
Sep 25, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Vivek VermaCharles B Simone
Nov 9, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Toshihiko DoiJaafar Bennouna
Aug 7, 2018·International Journal of Particle Therapy·Penny FangSteven H Lin

❮ Previous
Next ❯

Citations

Jul 25, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles B Simone
Oct 30, 2020·Expert Review of Anticancer Therapy·Nirav V PatelPranshu Mohindra
Jul 22, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J DoyenP Y Bondiau

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Breast : Official Journal of the European Society of Mastology
Gustavo Nader MartaHeloisa de Andrade Carvalho
Journal of Thoracic Disease
Melissa A L VyfhuisCharles B Simone
© 2021 Meta ULC. All rights reserved