Assessing pain objectively: the use of physiological markers

Anaesthesia
R CowenC Bantel

Abstract

Pain diagnosis and management would benefit from the development of objective markers of nociception and pain. Current research addressing this issue has focused on five main strategies, each with its own advantages and disadvantages. These encompass: (i) monitoring changes in the autonomic nervous system; (ii) biopotentials; (iii) neuroimaging; (iv) biological (bio-) markers; and (v) composite algorithms. Although each strategy has shown areas of promise, there are currently no validated objective markers of nociception or pain that can be recommended for clinical use. This article introduces the most important developments in the field and highlights shortcomings, with the aim of allowing the reader to make informed decisions about what trends to watch in the future.

References

Mar 1, 1992·Annals of the Rheumatic Diseases·R GuieuG Serratrice
Oct 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T J WasylakM E Jeans
Aug 1, 1989·British Journal of Anaesthesia·H Kehlet
Jun 1, 1986·Pain·G SandriniG Nappi
Jul 1, 1983·Electroencephalography and Clinical Neurophysiology·D Cohen, B N Cuffin
Sep 3, 1993·Neuroscience Letters·M Grönroos, A Pertovaara
May 1, 1993·Anesthesia and Analgesia·M D LarsonJ McGuire
Apr 8, 1999·British Journal of Anaesthesia·C Thornton, R M Sharpe
Jul 13, 1999·European Journal of Radiology·F Di SalleG Tedeschi
Sep 24, 1999·Pain·R Melzack
Oct 9, 1999·Journal of Neurophysiology·R C CoghillM J Iadarola
Apr 5, 2000·Progress in Neurobiology·R KakigiA Nakamura
Jul 19, 2000·Journal of Neurophysiology·K L CaseyS Minoshima
Aug 6, 2000·British Journal of Anaesthesia·J P Desborough
Oct 6, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·H StormL Morkrid
Dec 29, 2000·Cephalalgia : an International Journal of Headache·G SandriniG Nappi
Feb 22, 2001·Bulletin of Experimental Biology and Medicine·A V SyroveginT S Li
Feb 24, 2001·Sleep·G SandriniG Nappi
Mar 10, 2001·Clinical Pharmacology and Therapeutics·UNKNOWN Biomarkers Definitions Working Group.
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J A TaylorD L Eckberg
May 29, 2001·Anesthesia and Analgesia·A A AwadK H Shelley
Jul 12, 2001·Psychophysiology·L EdwardsD Carroll
Jul 19, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·H Storm
Aug 4, 2001·Autonomic Neuroscience : Basic & Clinical·J L ElghoziD Laude
Sep 29, 2001·Anesthesiology·J GreisenO Schmitz
Feb 15, 2002·Brain : a Journal of Neurology·Susanna J BantickIrene Tracey
Apr 5, 2002·Pain·V Skljarevski, N M Ramadan
Jun 1, 2002·Metabolism: Clinical and Experimental·Diane B Miller, James P O'Callaghan
Jul 26, 2002·Acta Anaesthesiologica Scandinavica·H StormJ C Raeder
Nov 20, 2002·Pediatric Research·Knut G HernesHanne Storm
Oct 3, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karla L MillerJohn M Pauly
Oct 29, 2003·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Carlo A Porro
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Mark P Jensen
Nov 26, 2003·Anesthesiology·Laura L YangMerlin D Larson
Jan 24, 2004·Anesthesiology·Robert K HofbauerM Catherine Bushnell
Feb 21, 2004·Science·Tor D WagerJonathan D Cohen
Oct 7, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·G D IannettiI Tracey

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Citations

Jan 4, 2017·Anaesthesia·K OdeA F Smith
Dec 13, 2016·Anesthesia and Analgesia·Andrew E NeiceMerlin D Larson
Jan 21, 2017·European Journal of Anaesthesiology·Eckhard MauermannWilhelm Ruppen
May 17, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Sebastiaan C GouloozeJ G Coen van Hasselt
Jun 20, 2017·Anesthesia and Analgesia·Georges DaccacheDominique Fletcher
Apr 20, 2018·Acta Anaesthesiologica Scandinavica·D WildemeerschG Hans
Dec 17, 2017·Science and Engineering Ethics·Giulio Mecacci, Pim Haselager
Oct 3, 2018·Minerva anestesiologica·Manuel Á Gómez-RíosJosé M Calvo-Vecino
Nov 22, 2018·Brain : a Journal of Neurology·André Mouraux, Gian Domenico Iannetti
Oct 18, 2019·Journal of Pediatric Psychology·Marianne J E van der HeijdenMonique van Dijk
Jan 10, 2020·Paediatric Drugs·Jean C DinhBridgette L Jones
Oct 11, 2019·The Journal of Hand Surgery, European Volume·Tom J Quick, Hazel Brown
Mar 17, 2020·The Journal of Dermatological Treatment·Haleigh E HarperHadar Lev-Tov
Apr 21, 2020·Scandinavian Journal of Caring Sciences·Alvisa PaleseSilvia Gonella
May 31, 2019·Pain·Gordon M MatthewsonTor D Wager
May 17, 2019·The Clinical Journal of Pain·Jiale HuDenise Harrison
Mar 12, 2019·Frontiers in Pharmacology·Dusica M StamenkovicCarsten Bantel
Oct 4, 2019·Pain Reports·Scott A HolmesDavid Borsook
Sep 19, 2020·Scientific Reports·Shohei OobaMunetaka Hirose
Feb 13, 2020·F1000Research·Xiaohan Xu, Yuguang Huang
Jun 20, 2019·Pain Management·Mai M MakhloufMichelle A Fortier
Aug 27, 2019·Journal of Intensive Care Medicine·Uri PollakPaul A Checchia
Apr 6, 2019·Scientific Reports·Raul Fernandez RojasKeng-Liang Ou
May 24, 2019·Journal of Clinical Monitoring and Computing·Sérgio VidePedro Amorim
Oct 6, 2020·Journal of Rehabilitation and Assistive Technologies Engineering·Louise Ir CastilloRafik Goubran
Apr 19, 2019·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Etienne Renaud-RoyPhilippe Richebé
Jun 28, 2018·Journal of Clinical Monitoring and Computing·Mingzhe JiangPasi Liljeberg
May 13, 2018·Fundamental & Clinical Pharmacology·Mostafa M HamdyAhmed Barakat
Dec 9, 2020·European Journal of Pain : EJP·Evy DhondtJessica Van Oosterwijck
Oct 25, 2020·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Youngmin Cho, Gwi-Ryung Son Hong
Jan 19, 2020·Neuroscience and Biobehavioral Reviews·Anna XuTheodore D Satterthwaite
Nov 12, 2020·Frontiers in Psychiatry·Daniella Levine, Danny Horesh
Nov 3, 2020·Journal of Medical Internet Research·Vinayak SmithBeverley Vollenhoven
Mar 3, 2021·Anaesthesia·H C Laycock, W Harrop-Griffiths

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