Assessing predictive accuracy for outcomes of ventilator-associated events in an international cohort: the EUVAE study

Intensive Care Medicine
Sergio Ramirez-Estradathe EU-VAE Study Investigators Group

Abstract

To analyze the impact on patient outcome of ventilator-associated events (VAEs) as defined by the Centers for Disease Control and Prevention (CDC) in 2008, 2013, and the correlation with ventilator-associated pneumonia (VAP) or tracheobronchitis (VAT). This was a prospective, observational, multicenter, international study conducted at 13 intensive care units (ICUs); thirty consecutive adults mechanically ventilated for ≥ 48 h per site were eligible, with daily follow-up being recorded in a collaborative web database; VAEs were assessed using the 2013 CDC classification and its 2015 update. A total of 2856 ventilator days in 244 patients were analyzed, identifying 33 VAP and 51 VAT episodes; 30-day ICU mortality was significantly higher (42.8 vs. 19.6%, p < 0.007) in patients with VAP than in those with VAT. According to the 2013 CDC definitions, 117 VAEs were identified: 113 (96%) were infection-related ventilator-associated complication-plus (IVAC-plus), while possible ventilator-associated pneumonia (PVAP) was found in 64 (56.6%) of them. VAE increased the number of ventilator days and prolonged ICU and hospital LOS (by 5, 11, and 12 days, respectively), with a trend towards increased 30-day mortality (43 vs 28%, p = 0.06). ...Continue Reading

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Jul 18, 2018·Expert Review of Anti-infective Therapy·Eshwara Vandana Kalwaje, Jordi Rello
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Aug 28, 2021·Antibiotics·Maxence RouyerSylvain Diamantis
Jan 11, 2022·Journal of Veterinary Emergency and Critical Care·Laura A CagleSteven E Epstein

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Methods Mentioned

BETA
sedation
bronchoalveolar lavage

Software Mentioned

R Core Team
R

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