Assessing real-time Zika risk in the United States

BioRxiv : the Preprint Server for Biology
Lauren A CastroLauren Ancel Meyers

Abstract

Background: Confirmed local transmission of Zika Virus (ZIKV) in Texas and Florida have heightened the need for early and accurate indicators of self-sustaining transmission in high risk areas across the southern United States. Given ZIKVs low reporting rates and the geographic variability in suitable conditions, a cluster of reported cases may reflect diverse scenarios, ranging from independent introductions to a self-sustaining local epidemic. Methods: We present a quantitative framework for real-time ZIKV risk assessment that captures uncertainty in case reporting, importations, and vector-human transmission dynamics. Results: We assessed county-level risk throughout Texas, as of summer 2016, and found that importation risk was concentrated in large metropolitan regions, while sustained ZIKV transmission risk is concentrated in the southeastern counties including the Houston metropolitan region and the Texas-Mexico border (where the sole autochthonous cases have occurred in 2016). We found that counties most likely to detect cases are not necessarily the most likely to experience epidemics, and used our framework to identify triggers to signal the start of an epidemic based on a policymakers propensity for risk. Conclusions:...Continue Reading

Related Concepts

Metropolitan
Southeast
Disease Transmission
Epidemiology
Disease Vectors
Zika Virus Disease (Disorder)
Public Health Domain
Zika virus (organism)
Epidemic Aspects
Risk Assessment

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