Assessing renal parenchymal volume on unenhanced CT as a marker for predicting renal function in patients with chronic kidney disease

Academic Radiology
Supriya GuptaDushyant Sahani

Abstract

To estimate renal volume in chronic kidney disease (CKD) patients using a semiautomated software and compare them with split renal function estimates from radionuclide renogram (RR). We proposed that renal volume from unenhanced computed tomography (CT) scans may serve as surrogate marker for assessing renal function in CKD patients. Unenhanced multidetector CT scans of 26 patients with CKD (estimated glomerular filtration rate [eGFR] <60 mL/kg/body surface area [BSA]) and 10 controls (eGFR >60 mL/kg/BSA) were analyzed to calculate renal volumes using a semiautomated software (AMIRAV5.2.0). Volumes obtained were then correlated with corresponding eGFR and split renal function estimates from RR. Volumes were also compared with those obtained on enhanced scans in 10 cases (five disease group, five controls). Bland-Altman analysis was used to assess agreement between methods. A moderately positive correlation was found between renal volume obtained on unenhanced CT and eGFR (r = 0.65, P < .0001), whereas a significantly high correlation with split function estimates from RR (r = 0.95, P < .001) was found. Bland-Altman analysis revealed a good agreement between renal volume from CT and renal function from RR (34/36 observations wer...Continue Reading

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Citations

Jun 29, 2015·Journal of Pediatric Surgery·Bo ShiWei-Dong Ren
Jan 19, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marissa J DeFreitasAlessia Fornoni
May 8, 2021·Journal of the American College of Radiology : JACR·UNKNOWN Expert Panel on Urologic ImagingMark E Lockhart

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