Assessing reproducibility and the effects of demographic variables on the normal macular layers using the Spectralis SD-OCT

Clinical Ophthalmology
Nauman HashmaniMaria Hashmani

Abstract

To quantify and view the possible influence of demographic variables on normal macular layers. Additionally, we wanted to assess the reproducibility using the Spectralis SD-OCT. A Spectralis SD-OCT machine using a commercially available algorithm was used to scan 242 healthy subjects in an outpatient setting. We examined retinal thicknesses in seven layers: retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL) and retinal pigment epithelium (RPE). Combined retinal thicknesses were expressed as inner retinal layer (IRL), photoreceptor layer (PL) and total retinal thickness (TRT). Measurements were taken from each of the nine sectors defined by the Early Treatment Diabetic Retinopathy Study; the center was the fovea, the inner circle (IC) was 1-3 mm away, and the outer circle (OC) was 3-6 mm away. The TRT was thickest inferiorly in the IC, and superiorly in the OC. The RNFL (P=0.030), GCL (P=0.006), IPL (P=0.006), IRL (P=0.030), PL (P<0.001) and TRT (P=0.001) were found to be thicker in males. The GCL (r=0.078, P=0.001), IPL (r=0.079, P=0.001), IRL (r=0.072, P=0.002), PL (r=0.076, P=0.001) and TRT (r=0.090, P<0.00...Continue Reading

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Software Mentioned

Spectralis Family Acquisition Module
Statistical Package for the Social Sciences ( SPSS )

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