Assessing response to treatment in non--small-cell lung cancer: role of tumor volume evaluated by computed tomography

Clinical Lung Cancer
Friedrich D KnollmannMark A Socinski

Abstract

We set out to investigate whether volumetric tumor measurements allow for a prediction of treatment response, as measured by patient survival, in patients with advanced non-small-cell lung cancer (NSCLC). Patients with nonresectable NSCLC (stage III or IV, n = 100) who were repeatedly evaluated for treatment response by computed tomography (CT) were included in a Health Insurance Portability and Accountability Act (HIPAA)-compliant retrospective study. Tumor response was measured by comparing tumor volumes over time. Patient survival was compared with Response Evaluation Criteria in Solid Tumors (RECIST) using Kaplan-Meier survival statistics and Cox regression analysis. The median overall patient survival was 553 days (standard error, 146 days); for patients with stage III NSCLC, it was 822 days, and for patients with stage IV disease, 479 days. The survival differences were not statistically significant (P = .09). According to RECIST, 5 patients demonstrated complete response, 39 partial response, 44 stable disease, and 12 progressive disease. Patient survival was not significantly associated with RECIST class, the change of the sum of tumor diameters (P = .98), nor the change of the sum of volumetric tumor dimensions (P = .1...Continue Reading

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Citations

Mar 27, 2015·Investigative Radiology·Hyungjin KimHans-Ulrich Kauczor
Sep 5, 2017·The British Journal of Radiology·Iain PhillipsPhilip Evans
Sep 19, 2019·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Jessica J WaningerIssam El Naqa
Jun 6, 2018·European Radiology·Lisa L ChuFriedrich D Knollmann
Nov 15, 2018·European Radiology Experimental·Stefania RizzoMassimo Bellomi

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