Assessing risk factors of falls in cancer patients with chemotherapy-induced peripheral neurotoxicity.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Andreas A ArgyriouHaralabos P Kalofonos

Abstract

To identify the risk factors of falls in a well-characterized cohort of cancer patients with chemotherapy-induced peripheral neurotoxicity (CIPN). We studied 122 cancer patients experiencing any grade of CIPN, following completion of different chemotherapeutic regimens for various non-hematological malignancies. The results of the clinical examination were summarized by means of the Total Neuropathy Score-clinical version (TNSc®). A neurophysiological examination was also carried out. Among 122 patients, 21 (17.2%) of them reported falls. These were 7 males and 14 females with a mean age of 57.3 ± 8.1 years. All of them (21; 100%) had grade 3 CIPN, according to TNSc® with a median value of 15. Univariate analysis showed that the following variables were strongly associated with falls: TNSc® score of > 14 corresponding to grade 3 CIPN, evidence of motor impairment, evidence of sensory ataxia with positive Romberg sign, and decrease of sural a-SAP > 50% from the baseline value. Multivariate regression analysis failed to define independent predictors of falls. However, ROC analysis demonstrated that a discriminative TNSc® cutoff value of > 14 predicted falls with a sensitivity of 100% and specificity of 87%, whereas sensory ataxia...Continue Reading

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Mar 1, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·J S GewandterS G Mohile
Mar 29, 2014·Cancer Management and Research·Andreas A ArgyriouHaralabos P Kalofonos
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Feb 1, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G CavalettiW Grisold

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Citations

Nov 5, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Claudia LoretiLuca Padua
Dec 22, 2020·Journal of the Peripheral Nervous System : JPNS·Andreas A ArgyriouHaralabos P Kalofonos
Nov 7, 2020·The Journal of Nutrition, Health & Aging·F M Runzer-ColmenaresJ F Parodi
Jun 29, 2021·Current Physical Medicine and Rehabilitation Reports·Jasmine Y ZhengMitra D McLarney
Aug 7, 2021·Journal of Personalized Medicine·Roser VelascoAndreas A Argyriou

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