Assessing risk of liver enzyme elevation in patients with immune-mediated diseases and different hepatitis B virus serostatus receiving anti-TNF agents: a nested case-control study

Arthritis Research & Therapy
Ying-Ming ChiuK Arnold Chan

Abstract

Liver enzyme elevation is an important and common adverse effect among patients with immune-mediated diseases who receive tumour necrosis factor inhibitors (anti-TNF), and has various causes. Hence, we evaluated the relative risks of developing liver enzyme elevation in anti-TNF users with differing hepatitis B virus (HBV) infection status. At a hospital in central Taiwan, 407 patients with rheumatoid arthritis, ankylosing spondylitis, or psoriasis/psoriatic arthritis received anti-TNF therapy between 1 January 2004 and 30 June 2012. We performed a nested case-control study (n = 368) of cases with serum alanine aminotransferase (ALT) > 40 international units/L ≤ 12 months after starting anti-TNF therapy, and corresponding controls without liver enzyme elevation. Conditional logistic regression was used to evaluate associations between liver enzyme elevation and HBV serostatus, as well as other risk factors. Thirty cases were compared to 338 controls. After adjustment for potential confounders, HBV surface antigen-positive (HBsAg+) serostatus was associated with substantially higher likelihood of developing elevated ALT (adjusted odds ratio 7.91, 95% confidence interval (CI) 2.16-31.31) relative to those with an uninfected HBV s...Continue Reading

References

Jun 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lucia CarulliPaola Loria
Mar 7, 2007·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chien-Hung ChenJin-Chuan Sheu
Mar 28, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W Ray KimUNKNOWN Public Policy Committee of the American Association for the Study of Liver Disease
Jan 29, 2010·Internal and Emergency Medicine·Stefano ManciniLuca Roncucci
May 8, 2010·Annals of the Rheumatic Diseases·Jeremy SokoloveUNKNOWN CORRONA Investigators
Jun 22, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert J FontanaJay H Hoofnagle
Jan 26, 2011·Nature Reviews. Rheumatology·Guruprasad P Aithal
Oct 26, 2011·World Journal of Gastroenterology : WJG·Claudio M MastroianniVincenzo Vullo
Nov 8, 2011·JAMA : the Journal of the American Medical Association·Carlos G GrijalvaJeffrey R Curtis
Dec 14, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Eiji Tanaka, Yukitomo Urata
Dec 23, 2011·Expert Opinion on Biological Therapy·Mauro ViganòMassimo Colombo
Oct 24, 2014·World Journal of Gastroenterology : WJG·Marco BertolottiPaola Loria

❮ Previous
Next ❯

Citations

Feb 2, 2019·Expert Opinion on Drug Safety·Giuseppe MurdacaFrancesco Puppo

❮ Previous
Next ❯

Software Mentioned

LogXact
Cytel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology
Chuan-Tong Lu, Guo-Sheng Gao
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Hui ZhangSonia Hernández-Díaz
© 2022 Meta ULC. All rights reserved