Assessing Risks of Polypharmacy Involving Medications With Anticholinergic Properties.

Annals of Family Medicine
Peter HanlonFrances S Mair

Abstract

Anticholinergic burden (ACB), the cumulative effect of anticholinergic medications, is associated with adverse outcomes in older people but is less studied in middle-aged populations. Numerous scales exist to quantify ACB. The aims of this study were to quantify ACB in a large cohort using the 10 most common anticholinergic scales, to assess the association of each scale with adverse outcomes, and to assess overlap in populations identified by each scale. We performed a longitudinal analysis of the UK Biobank community cohort (502,538 participants, baseline age: 37-73 years, median years of follow-up: 6.2). The ACB was calculated at baseline using 10 scales. Baseline data were linked to national mortality register records and hospital episode statistics. The primary outcome was a composite of all-cause mortality and major adverse cardiovascular event (MACE). Secondary outcomes were all-cause mortality, MACE, hospital admission for fall/fracture, and hospital admission with dementia/delirium. Cox proportional hazards models (hazard ratio [HR], 95% CI) quantified associations between ACB scales and outcomes adjusted for age, sex, socioeconomic status, body mass index, smoking status, alcohol use, physical activity, and morbidity ...Continue Reading

Citations

May 30, 2020·International Journal of Environmental Research and Public Health·Patricia Amoros-ReboredoConxita Mestres
Mar 9, 2021·Journal of Alzheimer's Disease : JAD·Jure MurRiccardo E Marioni
May 27, 2021·Therapeutic Advances in Drug Safety·Maria Herrero-ZazoVictoria L Keevil
Jun 27, 2021·International Journal of Clinical Pharmacy·Carrie StewartFrances S Mair
Aug 20, 2021·British Journal of Clinical Pharmacology·Jure MurTom C Russ

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