Assessing similarities and disparities in the skin microbiota between wild and laboratory populations of house mice.

The ISME Journal
Meriem BelheouaneJohn F Baines

Abstract

The house mouse is a key model organism in skin research including host-microbiota interactions, yet little is known about the skin microbiota of free-living mice. It is similarly unclear how closely laboratory mice, which typically live under exceptionally hygienic conditions, resemble the ancestral state of microbial variation in the wild. In this study, we sampled an area spanning 270 km2 in south-west France and collected 203 wild Mus musculus domesticus. We profiled the ear skin microbiota on standing and active communities (DNA-based and RNA-based 16 rRNA gene sequencing, respectively), and compared multiple community aspects between wild-caught and laboratory-reared mice kept in distinct facilities. Compared to lab mice, we reveal the skin microbiota of wild mice on the one hand to be unique in their composition within the Staphylococcus genus, with a majority of sequences most closely matching known novobiocin-resistant species, and display evidence of a rare biosphere. On the other hand, despite drastic disparities between natural and laboratory environments, we find that shared taxa nonetheless make up the majority of the core skin microbiota of both wild- and laboratory skin communities, suggesting that mammalian ski...Continue Reading

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Citations

Apr 2, 2021·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Axel Kornerup Hansen, Camilla Hartmann Friis Hansen

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Datasets Mentioned

BETA
KM45013

Methods Mentioned

BETA
dissection
PCR
electrophoresis

Software Mentioned

Lab
randomForest
DADA2
GenoDive
R package
Phyloseq
Decontam
MEGA
SplitsTree
Geneious

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