PMID: 11321611Apr 26, 2001Paper

Assessing supraspinal modulation of pain perception in individuals at risk for hypertension

Psychophysiology
Christopher R France, S Suchowiecki

Abstract

In this study we tested the hypothesis that hypoalgesia in individuals at risk for hypertension is related to enhanced activation of supraspinal pain modulation systems. Supraspinal inhibition of pain signals was assessed using a diffuse noxious inhibitory control paradigm, in which a noxious conditioning stimulus was used to suppress pain in response to a noxious test stimulus applied to a remote area of the body. Specifically, the nociceptive flexion reflex (NFR) was assessed in 113 healthy young adults before, during, and after exposure to forearm tourniquet ischemia. Consistent with previous evidence of hypoalgesia in individuals at risk for hypertension, offspring of hypertensive individuals exhibited significantly higher NFR thresholds than offspring of normotensive persons. Although NFR activity was significantly decreased in all participants during concomitant application of forearm ischemia, the degree of attenuation of NFR activity was not significantly different as a function of risk for hypertension.

Citations

Feb 22, 2005·Psychophysiology·Mustafa al'AbsiLorentz E Wittmers
Mar 24, 2006·Psychosomatic Medicine·Mustafa al'AbsiLorentz Wittmers
Oct 9, 2013·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Jennifer L DelVenturaJamie L Rhudy
Apr 2, 2010·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Phillip J QuartanaJohn W Burns
Feb 1, 2012·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Emily J Bartley, Jamie L Rhudy
Jul 10, 2012·The Journal of Pain : Official Journal of the American Pain Society·Satin L MartinJamie L Rhudy
Jul 4, 2015·Journal of Sports Sciences·Masataka UmedaShelby C Hilliard
Apr 18, 2008·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Jamie L RhudyChristopher R France
Apr 26, 2008·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Louisa EdwardsUna Martin
Sep 24, 2005·Psychophysiology·Jamie L RhudyPhilip Rambo
Apr 29, 2009·Veterinary Anaesthesia and Analgesia·Alessandra BergadanoClaudia Spadavecchia
Mar 26, 2004·The Journal of Pain : Official Journal of the American Pain Society·Dane B CookRod K Dishman
Jan 3, 2006·Progress in Neurobiology·Giorgio SandriniJean Claude Willer
Oct 22, 2013·Biological Psychology·Jamie L RhudyEllen L Terry
Apr 16, 2016·Psychophysiology·Raymonde ScheurenFernand Anton
Sep 5, 2014·The Clinical Journal of Pain·Emily J BartleyJamie L Rhudy
May 8, 2007·Pain·Claudia M CampbellRoger B Fillingim
Jan 23, 2009·Pain·Christopher R FranceJoel Katz
May 26, 2017·European Journal of Pain : EJP·S KrafftR Ruscheweyh
May 25, 2005·Pain·Stephen BruehlMustafa al'Absi
Nov 13, 2018·Anesthesiology·Heberto Suarez-RocaWilliam Maixner
Jul 4, 2019·The Clinical Journal of Pain·Evy DhondtJessica Van Oosterwijck

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