Assessing the accuracy of adherence and sexual behaviour data in the MDP301 vaginal microbicides trial using a mixed methods and triangulation model.

PloS One
Robert PoolSheena McCormack

Abstract

Accurate data on adherence and sexual behaviour are crucial in microbicide (and other HIV-related) research. In the absence of a "gold standard" the collection of such data relies largely on participant self-reporting. The Microbicides Development Programme has developed a mixed method/triangulation model for generating more accurate data on adherence and sexual behaviour. Data were collected from a random subsample of 725 women using structured case record form (CRF) interviews, coital diaries (CD) and in-depth interviews (IDI). Returned used and unused gel applicators were counted and additional data collected through focus group discussions and ethnography. The model is described in detail in a companion paper [1]. When CRF, CD and IDI are compared there is some inconsistency with regard to reporting of sexual behaviour, gel or condom use in more than half. Inaccuracies are least prevalent in the IDI and most prevalent in the CRF, where participants tend to under-report frequency of sex and gel and condom use. Women reported more sex, gel and condom use than their partners. IDI data on adherence match the applicator-return data more closely than the CRF. The main reasons for inaccuracies are participants forgetting, intervie...Continue Reading

Citations

Dec 1, 2010·African Journal of AIDS Research : AJAR·Jonathan Stadler, Eirik Saethre
Jun 14, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sheena M McCormackMyron S Cohen
Nov 28, 2012·Current HIV/AIDS Reports·Ariane van der StratenAlexandra Minnis
Oct 10, 2014·Sexually Transmitted Diseases·Kerri J PenroseUNKNOWN MTN Biomedical Sciences Working Group and the HPTN 035 Protocol Team
Nov 17, 2011·Culture, Health & Sexuality·Emilie Venables, Jonathan Stadler
Apr 27, 2010·Anthropology & Medicine·Eirik J Saethre, Jonathan Stadler
Apr 9, 2013·Journal of the International AIDS Society·Cynthia WoodsongSheena McCormack
Mar 27, 2016·Journal of Pharmaceutical and Biomedical Analysis·Patrick SpenceBríd Devlin
Feb 13, 2013·Journal of Clinical Pharmacology·Timothy E MoreyDonn M Dennis
Apr 12, 2014·Social Science & Medicine·Jonathan StadlerHelen Rees
Jul 19, 2012·PloS One·Catherine M MontgomeryRobert Pool
Oct 21, 2016·AIDS and Behavior·Jeeva MoodleyGita Ramjee
Jun 30, 2018·BMC Public Health·Nicola DesmondSally Theobald
Apr 26, 2017·AIDS·Elizabeth T MontgomeryUNKNOWN MTN-020/ASPIRE Study

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