Jun 21, 2016

Assessing the clinical utility of genomic expression data across human cancers

Oncotarget
Xinsen XuChang Liu

Abstract

Cancer molecular profiling provides better understanding of tumor mechanisms and helps to improve the existing cancer management. Here we present the gene expression signatures from ~9000 human tumors with clinical information across 32 malignancies from The Cancer Genome Atlas project (TCGA). Major predictors from the RNA sequencing data that were significantly correlated with cancer survival were identified. The expression level of these prognostic genes revealed significant genomic pathways that were clinically relevant to survival outcomes across human cancers. Furthermore, it is shown that in most cancer types, combinations of these genomic signatures with clinical information might yield improved predictions. Thus, with respect to clinical utility, our study reveals the promising values of genomic data from the pan-cancer perspective.

  • References29
  • Citations4

Mentioned in this Paper

Study
Biochemical Pathway
Genome
Genes
Sequence Determinations, RNA
Neoplasms
Molecular Profiling
Tumor Markers
Gene Expression
Genomics

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