Assessing the contributions of the LiaS histidine kinase to the innate resistance of Listeria monocytogenes to nisin, cephalosporins, and disinfectants.

Applied and Environmental Microbiology
Barry CollinsR Paul Ross

Abstract

The Listeria monocytogenes LiaSR two-component system (2CS) encoded by lmo1021 and lmo1022 plays an important role in resistance to the food preservative nisin. A nonpolar deletion in the histidine kinase-encoding component (ΔliaS) resulted in a 4-fold increase in nisin resistance. In contrast, the ΔliaS strain exhibited increased sensitivity to a number of cephalosporin antibiotics (and was also altered with respect to its response to a variety of other antimicrobials, including the active agents of a number of disinfectants). This pattern of increased nisin resistance and reduced cephalosporin resistance in L. monocytogenes has previously been associated with mutation of a second histidine kinase, LisK, which is a predicted regulator of liaS and a penicillin binding protein encoded by lmo2229. We noted that lmo2229 transcription is increased in the ΔliaS mutant and in a ΔliaS ΔlisK double mutant and that disruption of lmo2229 in the ΔliaS ΔlisK mutant resulted in a dramatic sensitization to nisin but had a relatively minor impact on cephalosporin resistance. We anticipate that further efforts to unravel the complex mechanisms by which LiaSR impacts on the antimicrobial resistance of L. monocytogenes could facilitate the devel...Continue Reading

References

May 1, 1986·Antimicrobial Agents and Chemotherapy·R D HoulsbyG O Chavez
Feb 1, 1983·Biochemical Pharmacology·J B HallG W Read
Nov 1, 1996·Veterinary Surgery : VS·W P StubbsP S Kubilis
Feb 7, 2001·Applied and Environmental Microbiology·S McGrathD van Sinderen
Apr 20, 2001·Molecular Microbiology·P D CotterC Hill
Jun 20, 2002·The British Journal of Dermatology·S D MorrisJ P McFadden
Jul 27, 2004·Antimicrobial Agents and Chemotherapy·Thorsten MascherJohn D Helmann
Sep 4, 2004·Applied and Environmental Microbiology·Jonathan O'DriscollDouwe Van Sinderen
Aug 17, 2005·Molecular Microbiology·Pierre MandinPascale Cossart
Nov 25, 2005·Letters in Applied Microbiology·G MaurielloD Ercolini
Mar 7, 2006·Applied and Environmental Microbiology·Máire BegleyR Paul Ross
Apr 28, 2006·Antimicrobial Agents and Chemotherapy·Naomi E KramerOscar P Kuipers
Jun 6, 2006·International Journal of Hygiene and Environmental Health·Milind S ShintreShanta M Modak
Jun 23, 2006·FEMS Microbiology Letters·Caitriona M GuinaneR Paul Ross
Sep 29, 2006·Antimicrobial Agents and Chemotherapy·S GardeteA Tomasz
Jun 20, 2007·Journal of Medical Microbiology·Mary C ReaColin Hill
Mar 14, 2008·Current Protein & Peptide Science·Lorraine A DraperPaul D Cotter
Jan 2, 2009·Microbiology·Jiaqin Zhang, Indranil Biswas
Jul 7, 2009·Annual Review of Microbiology·Rong Gao, Ann M Stock
Sep 15, 2009·Applied and Environmental Microbiology·Mette E HansenPeter R Jensen
Feb 1, 2011·International Journal of Food Microbiology·Brigitte Carpentier, Olivier Cerf

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Citations

Jul 16, 2013·Applied and Environmental Microbiology·Teresa M BergholzKathryn J Boor
Jun 12, 2013·PloS One·Jacqueline AbranchesJosé A Lemos
Mar 29, 2014·International Journal of Microbiology·Deepansh Sharma, Baljeet Singh Saharan
Nov 20, 2014·Microbiology·Maria do Carmo de Freire BastosOlinda Cabral da Silva Santos
Jun 16, 2016·Future Medicinal Chemistry·Fernando CoronaJosé L Martínez
Oct 25, 2016·International Journal of Antimicrobial Agents·Varish AhmadMughees Uddin Siddiqui
Mar 20, 2015·Microbiology and Molecular Biology Reviews : MMBR·Lorraine A DraperR Paul Ross
Mar 16, 2017·Archives of Microbiology·Nathan WallaceYvonne Sun
Oct 17, 2018·Frontiers in Microbiology·Leon M T DicksAnton D van Staden
Nov 18, 2018·Foodborne Pathogens and Disease·Christina Susanne HölzelKarin Schwaiger
Dec 18, 2018·Frontiers in Microbiology·Florentina Ionela BucurAnca Ioana Nicolau
Oct 14, 2017·FEMS Microbiology Letters·Cameron ParsonsSophia Kathariou
Sep 26, 2020·Frontiers in Microbiology·Santosh Kumar TiwariMichael L Chikindas
Jun 27, 2020·Applied Microbiology and Biotechnology·Xiaobing JiangLei Shi
Nov 18, 2020·FEMS Microbiology Letters·Maja Z BrunhedePascal Piveteau
Sep 3, 2020·FEMS Microbiology Reviews·Samira SoltaniIsmail Fliss
Sep 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Amin N OlaimatRichard A Holley
Mar 11, 2021·Critical Reviews in Microbiology·Ana Andréa Teixeira BarbosaSilvio Santana Dolabella
Mar 23, 2021·Frontiers in Bioengineering and Biotechnology·Lieke A van GijtenbeekGunnar Oregaard

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