Assessing the effect of natural selection in malaria parasites

Trends in Parasitology
Ananias A EscalanteAltaf A Lal

Abstract

There are few concepts that have been used across disciplines; one of them is natural selection. The impact that this process has on parasite genetic diversity is reviewed here by discussing examples on drug resistance and vaccine antigens. Emphasis is made on how mechanisms need to be addressed rather than associations, and how such investigations were out of reach of biomedical researchers only a decade ago.

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Citations

Jul 16, 2009·Malaria Journal·Tepanata PumpaiboolPongchai Harnyuttanakorn
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Stephen M RichNathan D Wolfe
Nov 5, 2010·PLoS Neglected Tropical Diseases·Paula M LuzAlison P Galvani
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