Assessing the effectiveness of antiretroviral regimens in cohort studies involving HIV-positive injection drug users.

AIDS
Viviane Dias LimaJulio S G Montaner

Abstract

We compared the effectiveness of different highly active antiretroviral therapy (HAART) regimens considering, separately, history of injection drug use (IDU) (yes/no). DESIGN, METHODS: A total of 1163 HIV-infected patients initiated HAART between 1 January 2000 and 28 February 2009 in British Columbia, Canada, and were followed until 28 February 2010. HAART effectiveness was measured by the ability to achieve viral suppression below 50 copies/ml at 6 months. We compared HAART regimens containing efavirenz and boosted atazanavir. We developed logistic regression models using different techniques to control for potential confounders. Among the 1163 patients, 796 (68%) achieved viral suppression at 6 months (32% reporting a history of IDU). Different confounding models yielded very similar odds ratios for achieving viral suppression. Boosted atazanavir-based HAART demonstrated to be the most effective regimen, showing a surprisingly higher benefit for patients with a history of IDU (odds ratios from different models ranged from 1.74-1.95 to 1.45-1.51). The literature has conflicting results regarding the effectiveness of HAART to treat HIV infection among those with a history of IDU. We have shown that most patients, with and with...Continue Reading

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Citations

Jun 23, 2015·Addictive Behaviors Reports·Cheyenne JohnsonEvan Wood
Apr 12, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Philip A ChanRami Kantor
Mar 19, 2014·International Journal of Epidemiology·Sophie PattersonEvan Wood
Jun 19, 2013·AIDS Care·Viviane Dias LimaJulio S G Montaner

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