Assessing the effectiveness of AS-48 in experimental mice models of Chagas' disease.

The Journal of Antimicrobial Chemotherapy
Rubén Martín-EscolanoClotilde Marín

Abstract

We report the in vivo trypanocidal activity of the bacteriocin AS-48 (lacking toxicity), which is produced by Enterococcus faecalis, against the flagellated protozoan Trypanosoma cruzi, the aetiological agent of Chagas' disease. We determined the in vivo activity of AS-48 against the T. cruzi Arequipa strain in BALB/c mice (in both acute and chronic phases of Chagas' disease). We evaluated the parasitaemia, the reactivation of parasitaemia after immunosuppression and the nested parasites in the chronic phase by PCR in target tissues. AS-48 reduced the parasitaemia profile in acute infection and showed a noteworthy reduction in the parasitic load in chronic infection after immunosuppression according to the results obtained by PCR (double-checking to demonstrate cure). AS-48 is a promising alternative that provides a step forward in the development of a new therapy against Chagas' disease.

References

Nov 1, 1989·Analytical Biochemistry·S C Gill, P H von Hippel
May 16, 2000·Revista Do Instituto De Medicina Tropical De São Paulo·D Fabbro De SuasnábarN Amicone
Sep 16, 2000·Trends in Microbiology·R E Hancock, G Diamond
Nov 19, 2003·Journal of Molecular Biology·M J Sánchez-BarrenaA Albert
Mar 28, 2008·Proceedings of the National Academy of Sciences of the United States of America·Shane R WilkinsonIan Cheeseman
Mar 30, 2010·Microbes and Infection·Hisako Kayama, Kiyoshi Takeda
Apr 8, 2011·Current Pharmaceutical Biotechnology·Manuel Montalbán-LópezMercedes Maqueda
Sep 14, 2011·PLoS Neglected Tropical Diseases·Grasiella AndrianiAna Rodriguez
Nov 4, 2011·Human Vaccines·Israel Quijano-Hernandez, Eric Dumonteil
Jan 13, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maria Aparecida Shikanai-Yasuda, Noemia Barbosa Carvalho
Jan 17, 2012·Progress in Lipid Research·Vitor TeixeiraMargarida Bastos
Jan 17, 2012·PLoS Neglected Tropical Diseases·Solomon NwakaTimothy Geary
May 31, 2012·TheScientificWorldJournal·Ángeles López-CéspedesClotilde Marín
Oct 20, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min-Duk SeoBong-Jin Lee
Apr 9, 2013·Toxicon : Official Journal of the International Society on Toxinology·Camila M AdadeThaïs Souto-Padrón
Sep 24, 2014·Journal of Biomolecular Screening·Eric Chatelain
Oct 16, 2014·Memórias do Instituto Oswaldo Cruz·Bianca ZingalesUNKNOWN Chagas Clinical Research Platform Meeting
Mar 31, 2015·Journal of Structural Biology·Rubén CebriánMaría José Sánchez-Barrena
Jul 30, 2015·The New England Journal of Medicine·Caryn Bern
Nov 3, 2015·European Journal of Medicinal Chemistry·Francisco OlmoManuel Sánchez-Moreno
Mar 31, 2016·Vaccine·Coreen M BeaumierMaria Elena Bottazzi
Dec 31, 2016·The Journal of Microbiology·Hee-Kyoung KangYoonkyung Park
Feb 9, 2017·Antimicrobial Agents and Chemotherapy·María Ángeles AbengózarLuis Rivas
Jul 20, 2017·Bioorganic & Medicinal Chemistry·Jolene L Lau, Michael K Dunn
Apr 13, 2018·International Journal for Parasitology. Drugs and Drug Resistance·Marta Martínez-GarcíaJosé M Pérez-Victoria
Jun 9, 2018·Journal of Medicinal Chemistry·Rubén Martín-EscolanoManuel Sánchez-Moreno
Jul 11, 2018·Antimicrobial Agents and Chemotherapy·Clara Aguilar-PérezJosé A Aínsa
Apr 7, 2019·International Journal for Parasitology. Drugs and Drug Resistance·Rubén Martín-EscolanoClotilde Marín
Jul 31, 2019·Journal of Advanced Research·Rubén CebriánMercedes Maqueda

❮ Previous
Next ❯

Citations

Sep 6, 2020·Antibiotics·Manuel Montalbán-LópezMercedes Maqueda
Apr 10, 2021·Journal of Experimental Pharmacology·Ana Lia MazzetiVanessa Carla Furtado Mosqueira
May 4, 2021·Oxidative Medicine and Cellular Longevity·Fuqing HuangJin Zhong
May 4, 2021·Frontiers in Microbiology·Diego Francisco Benítez-ChaoJosé Rubén Morones-Ramírez

❮ Previous
Next ❯

Related Concepts

Related Papers

International Journal for Parasitology. Drugs and Drug Resistance
Rubén Martín-EscolanoClotilde Marín
Journal of Molecular Biology
Maria José Sanchez-BarrenaArmando Albert
© 2021 Meta ULC. All rights reserved