Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion

Scientific Reports
M M C ArrojaC McCabe

Abstract

The counter-regulatory axis, Angiotensin Converting Enzyme 2, Angiotensin-(1-7), Mas receptor (ACE2/Ang-1-7/MasR), of the renin angiotensin system (RAS) is a potential therapeutic target in stroke, with Ang-(1-7) reported to have neuroprotective effects in pre-clinical stroke models. Here, an extensive investigation of the functional and mechanistic effects of Ang-(1-7) was performed in a rodent model of stroke. Using longitudinal magnetic resonance imaging (MRI) it was observed that central administration of Ang-(1-7) following transient middle cerebral artery occlusion (MCAO) increased the amount of tissue salvage compared to reperfusion alone. This protective effect was not due to early changes in blood brain barrier (BBB) permeability, microglia activation or inflammatory gene expression. However, increases in NADPH oxidase 1 (Nox1) mRNA expression were observed in the treatment group compared to control. In order to determine whether Ang-(1-7) has direct cerebrovascular effects, laser speckle contrast imaging (LSCI) was performed to measure dynamic changes in cortical perfusion following reperfusion. Delivery of Ang-(1-7) did not have any effect on cortical perfusion following reperfusion however; it showed an indication t...Continue Reading

References

Dec 1, 1976·Clinical Science and Molecular Medicine. Supplement·P SchellingD Ganten
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Jan 31, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thomas WaltherGünter Mies
Dec 10, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Qiang ShenTimothy Q Duong
May 7, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Min LouJuraj Culman
Jul 16, 2005·Stroke; a Journal of Cerebral Circulation·Roland VeltkampMarkus Schwaninger
May 15, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Lenice K BeckerMaria J Campagnole-Santos
Jul 7, 2007·Cardiovascular Drug Reviews·Aaron J Trask, Carlos M Ferrario
Oct 6, 2007·Stroke; a Journal of Cerebral Circulation·Andrei V AlexandrovAnne W Alexandrov
Apr 18, 2008·European Journal of Pharmacology·Dilek IusufAnton J M Roks
May 15, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Chien-Yuan LinTeng-Nan Lin
Aug 6, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Deepu R PillaiFelix Schlachetzki
Jul 27, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Matthew J DurandJulian H Lombard
Jun 21, 2011·Experimental Physiology·Adam P MeccaColin Sumners
Nov 24, 2011·Annals of Biomedical Engineering·Andrew K Dunn
Apr 16, 2013·Neuropharmacology·Robert W RegenhardtColin Sumners
Oct 22, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·D D McLeodN J Spratt
Jan 21, 2014·Neuropharmacology·Ji ChenYanfang Chen
Jan 30, 2014·Clinical and Experimental Pharmacology & Physiology·Hamdollah PanahpourShahab Bohlooli
Dec 20, 2014·European Journal of Pharmacology·Jitao WuDan Wang
Feb 12, 2015·The New England Journal of Medicine·Mayank GoyalUNKNOWN ESCAPE Trial Investigators
Oct 9, 2015·Journal of Neurochemistry·Meng LiuColin Sumners
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Brad A SutherlandAlastair M Buchan
Mar 5, 2016·Experimental & Translational Stroke Medicine·Elisa CuccioneSimone Beretta
Oct 26, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Narayanaswamy VenketasubramanianDeidre A De Silva
Apr 2, 2017·Stroke; a Journal of Cerebral Circulation·Kouji WakayamaRyuichi Morishita
Apr 4, 2017·Clinical Medicine : Journal of the Royal College of Physicians of London·Salwa El Tawil, Keith W Muir
Jul 14, 2017·Journal of Neurointerventional Surgery·Akiyo SadatoYuichi Hirose
Aug 2, 2017·Protein and Peptide Letters·Patricia Lanza de MoraesAnderson J Ferreira

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques

Software Mentioned

Paravision
MathWorks
ARRIVE
Matlab
Image J

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Related Papers

Journal of Geriatric Cardiology : JGC
Feng ZhangHong Chen
Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
Anderson J Ferreira, Robson A S Santos
TheScientificWorldJournal
Marc Dilauro, Kevin D Burns
© 2022 Meta ULC. All rights reserved