Assessing the effects of body weight on subchondral bone formation with quantitative 18F-sodium fluoride PET.

Annals of Nuclear Medicine
Tiffany H KhawAbass Alavi

Abstract

The aim of this study was to quantify subchondral bone remodeling in the elbows, hands, knees, and feet using volumetric and metabolic parameters derived from 18F-sodium fluoride positron emission tomography (NaF-PET) and to assess the convergent validity of these parameters as an index of joint degeneration and preclinical osteoarthritis. A retrospective analysis was conducted in 34 subjects (32 males, 2 females) with metastatic bone disease who underwent full-body NaF-PET/CT scans. An adaptive contrast-oriented thresholding algorithm was applied to segment NaF-avid regions in the bilateral elbows, hands, knees, and feet of each subject, and metabolically active volume (MAV), maximum standardized uptake value (SUVmax), mean metabolic volumetric product (MVPmean), and partial volume-corrected MVPmean (cMVPmean) of the segmented regions were calculated. Global parameters for MAV, SUVmax, MVPmean, and cMVPmean were defined as the sum of the corresponding values in all the joints of a subject. Inter-rater reliability was determined with Lin's concordance correlation, and associations of global values with subject body weight and age were assessed with Pearson correlation and Spearman correlation analyses. Inter-rater reliability w...Continue Reading

References

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Feb 23, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Poul Flemming Høilund-CarlsenAbass Alavi
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Jun 12, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Poul F Høilund-CarlsenAbass Alavi
Nov 14, 2019·International Journal of Rheumatic Diseases·William Y RaynorJoshua F Baker

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Citations

Feb 17, 2021·PET Clinics·William Y RaynorMona-Elisabeth Revheim
Nov 22, 2020·PET Clinics·Abhijit J ChaudhariAbass Alavi

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