Assessing the efficacy of repeat resections in recurrent glioblastoma: a systematic review.

Neurosurgical Review
David BotrosDebraj Mukherjee

Abstract

The inevitable recurrence of glioblastoma (GBM) results in patients often undergoing multiple resections with questionable benefit to overall survival (OS). To systematically review and analyze prior studies examining the potential added benefit of repeat resection (RR) in recurrent GBM. We performed a PRISMA-compliant systematic review of literature published between 1969 to 2019 involving patients undergoing RR at GBM recurrence. The search yielded 3994 non-duplicate citations. Final abstraction included 43 articles, with 2 level II and 41 level III studies. The earliest paper we included was published in 1987 [1], and 35 identified papers (81.4%) were published within the last 10 years. The survival data of 9236 patients (55% male) were analyzed, with a median age of 56; 3726 patients underwent RR. In 31 studies with a comparable single-surgery-only cohort, 20 articles reported a statistically significant increase in OS with RR, 7 reported nonsignificant trends toward increased OS with RR, and 4 reported no significant increase in OS with RR. Twenty-two articles with multivariate analyses of Karnofsky performance scores and 17 articles with extent-of-resection reported these as significant prognostic factors of OS. In 26 stu...Continue Reading

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Citations

Dec 11, 2020·Disease Markers·Junsheng LiJizong Zhao
Feb 20, 2021·Radiation Oncology·Giuseppe MinnitiClaus Belka

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