Assessing the impact of alcohol consumption on the genetic contribution to mean corpuscular volume.

Human Molecular Genetics
Andrew ThompsonMunir Pirmohamed

Abstract

The relationship between the genetic loci that influence mean corpuscular volume (MCV) and those associated with excess alcohol drinking is unknown. We used white British participants from the UK Biobank (n = 362 595) to assess the association between alcohol consumption and MCV, and whether this was modulated by genetic factors. Multivariable regression was applied to identify predictors of MCV. GWAS, with and without stratification for alcohol consumption, determined how genetic variants influence MCV. SNPs in ADH1B, ADH1C and ALDH1B were used to construct a genetic score to test the assumption that acetaldehyde formation is an important determinant of MCV. Additional investigations using Mendelian randomization and phenome-wide association analysis were conducted. Increasing alcohol consumption by 40 g/week resulted in a 0.30% [95% confidence interval CI: 0.30-0.31%] increase in MCV (P < 1.0 × 10-320). Unstratified (irrespective of alcohol intake) GWAS identified 212 loci associated with MCV, of which 108 were novel. There was no heterogeneity of allelic effects by drinking status. No association was found between MCV and the genetic score generated from alcohol metabolizing genes. Mendelian randomization demonstrated a caus...Continue Reading

References

Oct 1, 1989·Alcoholism, Clinical and Experimental Research·R Hernández-MuñozC S Lieber
Dec 26, 2001·The Journal of Laboratory and Clinical Medicine·S MaruyamaK Umeki
May 18, 2005·Alcoholism, Clinical and Experimental Research·Leimin SunNils Homann
Apr 4, 2006·The Journal of Laboratory and Clinical Medicine·Heidi KoivistoOnni Niemelä
Sep 22, 2006·Clinical Medicine & Research·Florence AsliniaSteven H Yale
Nov 17, 2006·Development·Natalia MeierFrank Grosveld
Jan 18, 2008·The New England Journal of Medicine·Katrina J AllenDorota M Gertig
Jan 22, 2008·Blood·Tulene S KendrickEvan Ingley
Oct 29, 2009·Nature Genetics·Santhi K GaneshJing-Ping Lin
Jun 1, 2010·BMC Bioinformatics·Reedik Mägi, Andrew P Morris
Nov 3, 2010·The Journal of Experimental Medicine·LiQi LiPaul E Love
Oct 8, 2013·Nature Genetics·Cristen J WillerUNKNOWN Global Lipids Genetics Consortium
Jun 28, 2016·American Journal of Human Genetics·Nathalie ChamiGuillaume Lettre
Oct 16, 2018·Alcoholism, Clinical and Experimental Research·Howard J Edenberg, Jeanette N McClintick
Oct 24, 2018·Nature Genetics·Oriol Canela-XandriAlbert Tenesa
Jan 1, 2019·American Journal of Human Genetics·Gleb KichaevAlkes L Price
Jun 4, 2019·Clinical Hemorheology and Microcirculation·Roni BiranGregory Barshtein
Jun 14, 2019·PloS One·Robert W ReadJoseph J Grzymski
Jun 18, 2019·Lancet·Cedric AbatDidier Raoult
Jan 31, 2020·Science Advances·Andrew ThompsonMunir Pirmohamed

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

British Journal of Haematology
B S Bull, J C Westengard
British Journal of Haematology
G Brecher
© 2021 Meta ULC. All rights reserved