Assessing the impact of delayed blastulation using time lapse morphokinetics and preimplantation genetic testing in an IVF patient population

Journal of Assisted Reproduction and Genetics
Dana KimelmanMary Ellen Pavone

Abstract

There is clinical evidence that early cleavage timing parameters predictive of blastocyst development also correlate with embryo implantation potential. The aim of this study is to determine the developmental competency of embryos with delayed blastulation. Retrospective study performed from 2015 to 2016 at the Division of Reproductive Endocrinology and Infertility at Northwestern University. A total of 2,292 embryos from 524 patients were included. Day 6 blastocysts had statistically significant longer times for every time point analyzed than day 5 blastocysts (p < 0.001). We found no statistically significant difference in euploidy rates between day 5 (44%) and day 6 (41%) embryos (p = 0.573). t7 and t8 time points were independent predictors of euploidy after controlling for day of biopsy (p < 0.015 and p < 0.014, respectively). Intrauterine pregnancy (IUP) and live birth (LB) were less likely to occur after transferring day 6 embryos (p = 0.0033 and p = 0.0359) without previous genetic testing. However, in embryos that undergo preimplantation genetic testing for aneuploidy (PGT-A), there were no significant differences in IUP or LB rates. Early time-lapse points can be used to predict embryo development. Day of blastulation...Continue Reading

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Citations

Dec 19, 2020·Therapeutic Advances in Reproductive Health·Maria Giulia MinasiErmanno Greco
Dec 1, 2020·Reproductive Biomedicine Online·Omar SheblThomas Ebner
Oct 17, 2020·Fertility and Sterility·Dana B McQueenMary Ellen Pavone
Jul 6, 2021·F&S Reports·Mathilde BourdonPietro Santulli

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