Assessing the Impact of Efalizumab on Nail, Scalp and Palmoplantar Psoriasis and on Quality of Life: Results from a Multicentre, Open-label, Phase IIIb/IV Trial.

Archives of Drug Information
Andreas KatsambasMichel De La Brassinne

Abstract

This post-approval, open-label trial (n = 1266) assessed the efficacy of efalizumab, administered in accordance with the European label at that time, in patients with concomitant nail, scalp or palmoplantar psoriasis. Patients received subcutaneous efalizumab 1.0 mg/kg weekly for up to 20 weeks. By Week 12, an improvement from baseline of 50% or more was observed in 21.4% (181/844) of patients with nail psoriasis, 62.4% (718/1150) of patients with scalp psoriasis, and 51.4% (127/247) of patients with palmoplantar psoriasis. Quality of life improved throughout the trial, with a 50% median improvement in DLQI score after 12 weeks of treatment. Efalizumab showed promising efficacy in the treatment of nail, scalp and palmoplantar psoriasis, which was reflected in improvements in quality of life.

References

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Citations

Jan 5, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·M Sánchez-RegañaP Umbert-Millet
Feb 20, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·R G LangleyM P Heffernan
Aug 3, 2013·The Journal of Rheumatology·Kristina Callis DuffinPhilip J Mease
Nov 3, 2012·The Journal of Rheumatology·Kristina Callis DuffinPhilip J Mease
Feb 3, 2012·The Journal of Rheumatology·Jamie L WoodcockKristina Callis Duffin
Mar 3, 2011·The Journal of Rheumatology·Kristina Callis Duffin, Philip J Mease
Jun 3, 2014·The Journal of Rheumatology·Kristina Callis DuffinPhilip J Mease

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