Assessing the impact of the addition of pyriproxyfen on the durability of permethrin-treated bed nets in Burkina Faso: a compound-randomized controlled trial

Malaria Journal
Kobié H ToéN'Fale Sagnon

Abstract

Long-lasting insecticidal nets (LLINs) treated with pyrethroids are the foundation of malaria control in sub-Saharan Africa. Rising pyrethroid resistance in vectors, however, has driven the development of alternative net formulations. Here the durability of polyethylene nets with a novel combination of a pyrethroid, permethrin, and the insect juvenile hormone mimic, pyriproxyfen (PPF), compared to a standard permethrin LLIN, was assessed in rural Burkina Faso. A compound-randomized controlled trial was completed in two villages. In one village 326 of the PPF-permethrin nets (Olyset Duo) and 327 standard LLINs (Olyset) were distributed to assess bioefficacy. In a second village, 170 PPF-permethrin nets and 376 LLINs were distributed to assess survivorship. Nets were followed at 6-monthly intervals for 3 years. Bioefficacy was assessed by exposing permethrin-susceptible and resistant Anopheles gambiae sensu lato mosquito strains to standard World Health Organization (WHO) cone and tunnel tests with impacts on fertility measured in the resistant strain. Insecticide content was measured using high-performance liquid chromatography. LLIN survivorship was recorded with a questionnaire and assessed by comparing the physical integrity ...Continue Reading

References

Feb 23, 2008·Tropical Medicine & International Health : TM & IH·Audrey LenhartP J McCall
Oct 4, 2014·Emerging Infectious Diseases·Kobié H ToéHilary Ranson
Oct 18, 2016·Insect Biochemistry and Molecular Biology·Cristina YuntaMark J I Paine
Sep 16, 2016·Science Translational Medicine·Corine NguforMark Rowland
Apr 3, 2018·Travel Medicine and Infectious Disease·Jane Chiodini
Apr 4, 2018·Vaccine· World Health Organization
Aug 1, 2019·MedRxiv : the Preprint Server for Health Sciences·L. M. LorenzSarah J Moore

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Citations

Jan 21, 2021·Malaria Journal·Amy WheldrakeStephen J Russell

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Methods Mentioned

BETA
dissection

Software Mentioned

R
lme4
Dionex [UNK]
ggplot2

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