Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair

Environmental and Molecular Mutagenesis
Sharon B Cantor, Jenny Xie

Abstract

FANCJ (also known as BRIP1 or BACH1) is a DNA helicase that was originally identified by its direct interaction with the hereditary breast cancer protein, BRCA1. Similar to BRCA1, FANCJ function is essential for DNA repair and breast cancer suppression. FANCJ is also mutated in the cancer prone syndrome Fanconi anemia, for which patient cells are characterized by extreme sensitivity to agents that generate DNA interstand crosslinks. Unexpectedly, correction of the interstrand crosslink sensitivity of FANCJ-null patient cells did not require the FANCJ/BRCA1 interaction. Instead, FANCJ binding to the mismatch repair protein, MLH1 was required. Given this finding, we address the role of FANCJ and MLH1 in DNA crosslink processing and how their functions could be linked in checkpoint and/or recombination pathways. We speculate that after DNA crosslink processing and repair, the FANCJ/MLH1 interaction is critical for recovery and restart of replication. These ideas are considered and summarized in this review.

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Citations

Apr 25, 2012·Annals of Surgical Oncology·Ryota NakanishiYoshihiko Maehara
Feb 25, 2011·Future Oncology·Sharon B Cantor, Shawna Guillemette
Mar 2, 2016·Mutation Research·Sharon B Cantor, Sumeet Nayak
Dec 12, 2012·Mutation Research·Karen M Vasquez, Guliang Wang
Oct 16, 2012·Environmental and Molecular Mutagenesis·Shilpy Sharma, Christine E Canman
Dec 9, 2014·Cell Cycle·Sharon B Cantor, Robert M Brosh
Jun 28, 2016·Nucleic Acids Research·Colin G Wu, Maria Spies
Apr 2, 2020·World Journal of Gastroenterology : WJG·Ioannis A Voutsadakis

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