Assessing the performance of rotational spectroscopy in chiral analysis.

Chemical Science
Sérgio R DomingosMelanie Schnell

Abstract

The capabilities of rotational spectroscopy-based methods as tools to deliver accurate and precise chirality-sensitive information are still breaking ground, but their applicability in the challenging field of analytical chemistry is already clear. In this mini review, we explore the current abilities and challenges of two emergent techniques for chiral analysis based on rotational spectroscopy. For that, we will showcase the two methods (microwave 3-wave mixing and chiral tag rotational spectroscopy) while testing their performance to solve the absolute configuration and the enantiomeric excess of a blind sample containing a mixture of enantiomers of styrene oxide.

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Citations

Jan 17, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Fan XieYunjie Xu
Apr 21, 2021·Physical Chemistry Chemical Physics : PCCP·Junhua ChenWalther Caminati
Sep 22, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Christina Dindić, Ha Vinh Lam Nguyen
Oct 27, 2021·Chirality·Reilly E SonstromBrooks H Pate

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Methods Mentioned

BETA
circular dichroism
NMR

Software Mentioned

M3WM

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