PMID: 16523811Mar 10, 2006Paper

Assessing the prognostic significance of transrectal ultrasound extracapsular extension in prostate cancer

Clinical Oncology : a Journal of the Royal College of Radiologists
F YoonJ Izawa

Abstract

To determine the prognostic value of transrectal ultrasound (TRUS)-detected extraprostatic disease for prostate cancer in patients receiving radical external-beam radiation therapy (EBRT). A chart review of 181 patients treated with radical EBRT for prostate cancer was conducted. All patients underwent TRUS assessment by one radiologist. The median radiation dose delivered to the prostate was 66 Gy (range 53-70 Gy) in 33 fractions (range 20-39 fractions). Median follow-up time for all patients was 6.5 years. Sixty-four (35%) out of 181 patients were found to have extracapsular disease on TRUS. Clinical relapse was defined as the first occurrence of either salvage hormonal therapy administration by the treating oncologist or clinical, radiological, and/or pathologic evidence of recurrent or progressive disease. In terms of biochemical failure, two prognostic variable analyses were carried out using both the American Society for Therapeutic Radiology and Oncology (ASTRO) consensus guidelines and the Houston definition of biochemical failure. The primary end point for the prognostic variable analyses was time to first clinical or biochemical failure (CBF). For time to CBF using the ASTRO consensus guidelines for biochemical failur...Continue Reading

References

Sep 1, 1997·The Journal of Urology·G J O'DowdJ E Oesterling

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Citations

Feb 10, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Romina MoaveroPaolo Curatolo

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