Assessing the relation between coronary reflow and myocardial reflow

The American Journal of Cardiology
H Ito, K Iwakura

Abstract

Since the recognition that prompt reperfusion of the infarct-related artery decreases mortality after acute myocardial infarction (MI), we have been interested in optimizing therapeutic regimens to accelerate the establishment of infarct-related artery patency. Although the major endpoint of many angiographic trials has been the acquisition of a patent infarct-related artery, this may not correlate with actual tissue perfusion because of the no-reflow phenomenon. With myocardial contrast echocardiography (MCE), we assessed the success of myocardial reperfusion at the microvascular level in patients with an acute anterior MI. We documented that 21% of the study patients exhibited Thrombolysis in Myocardial infarction (TIMI) grade 2 flow after coronary angioplasty, and all of them showed substantial "no reflow" on MCE. Conversely, no reflow was observed on MCE in only 16% of patients with TIMI grade 3 flow. Early TIMI grade 3 flow resulted in a significantly better left ventricular functional outcome compared with those with TIMI grade 2. In view of microvascular perfusion, TIMI grade 2, despite the absence of coronary obstruction, cannot be regarded as successful reperfusion. Our study, using a Doppler guidewire probe, documente...Continue Reading

References

Dec 1, 1991·Catheterization and Cardiovascular Diagnosis·R M PomerantzD S Baim
Dec 1, 1974·The Journal of Clinical Investigation·R A KlonerR B Jennings

❮ Previous
Next ❯

Citations

Dec 15, 2010·Journal of Cardiovascular Translational Research·Stavros StavrakisJohn Nanas
Jan 22, 2002·Journal of Clinical Laser Medicine & Surgery
Jul 1, 2017·The International Journal of Cardiovascular Imaging·Mahmut YesinSüleyman Karakoyun
Feb 28, 2007·Contrast Media & Molecular Imaging·Alexis JacquierMaythem Saeed

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.