Assessing the reliability of uptake and elimination kinetics modelling approaches for estimating bioconcentration factors in the freshwater invertebrate, Gammarus pulex

The Science of the Total Environment
Thomas H MillerLeon P Barron

Abstract

This study considers whether the current standard toxicokinetic methods are an accurate and applicable assessment of xenobiotic exposure in an aquatic freshwater invertebrate. An in vivo exposure examined the uptake and elimination kinetics for eight pharmaceutical compounds in the amphipod crustacean, Gammarus pulex by measuring their concentrations in both biological material and in the exposure medium over a 96 h period. Selected pharmaceuticals included two anti-inflammatories (diclofenac and ibuprofen), two beta-blockers (propranolol and metoprolol), an anti-depressant (imipramine), an anti-histamine (ranitidine) and two beta-agonists (formoterol and terbutaline). Kinetic bioconcentration factors (BCFs) for the selected pharmaceuticals were derived from a first-order one-compartment model using either the simultaneous or sequential modelling methods. Using the simultaneous method for parameter estimation, BCF values ranged from 12 to 212. In contrast, the sequential method for parameter estimation resulted in bioconcentration factors ranging from 19 to 4533. Observed toxicokinetic plots showed statistically significant lack-of-fits and further interrogation of the models revealed a decreasing trend in the uptake rate const...Continue Reading

References

Aug 25, 2004·Marine Pollution Bulletin·Kevin V Thomas, Martin J Hilton
Jun 28, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Montserrat Solé, David R Livingstone
Jun 10, 2006·The Science of the Total Environment·Mark CraneTatiana Boucard
Sep 1, 2006·Archives of Environmental Contamination and Toxicology·Roman AshauerColin Brown
Jul 31, 2007·Toxicology Letters·Lars-Henrik HeckmannRichard M Sibly
Jul 31, 2010·Nature Reviews. Drug Discovery·Kiyohiko SuganoFrank Senner
Sep 24, 2010·Journal of Environmental Monitoring : JEM·Roman Ashauer, Beate I Escher
Sep 28, 2010·Environmental Toxicology and Chemistry·Mascha N RubachPaul J Van den Brink
Jan 10, 2012·Environmental Pollution·Melanie Meredith-WilliamsAlistair B A Boxall
Feb 11, 2012·Environmental Science & Technology·Roman AshauerBeate I Escher
Apr 25, 2014·Environmental Science & Technology·Anna-Maija NymanRoman Ashauer
Oct 22, 2014·Environmental Science & Technology·Laura J CarterAlistair B A Boxall

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Citations

May 28, 2016·Environmental Science & Technology·Andrea RöschJuliane Hollender
Jul 10, 2016·The Science of the Total Environment·Wenhong FanWen-Xiong Wang
Jan 10, 2018·Environmental Toxicology and Chemistry·Ciara Chun Chen, Dave Ta Fu Kuo
Mar 3, 2021·Environmental Science & Technology·Ana PrevišićMarko Rožman
Mar 9, 2021·Analytical Methods : Advancing Methods and Applications·Elisabeth Dohmann ChangNic R Bury
Jul 24, 2021·Journal of Agricultural and Food Chemistry·Jong-Hwan KimJong-Su Seo
Aug 18, 2018·Environmental Science & Technology·Nicole A MunzJuliane Hollender
Apr 2, 2020·Environmental Science & Technology·Kristoffer DalhoffNina Cedergreen
Mar 7, 2020·Ecotoxicology and Environmental Safety·Jerry Collince AcharJinho Jung

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