Assessing the reporting and scientific quality of meta-analyses of randomized controlled trials of treatments for anxiety disorders

The Annals of Pharmacotherapy
Basil G BerezaThomas R Einarson

Abstract

Meta-analyses of randomized controlled trials (RCTs) constitute the highest level of evidence, but their usefulness depends on their quality. To assess the reporting and scientific quality of meta-analyses of RCTs on treatments for anxiety disorders. Criteria for peer-reviewed, full-text retrieval included meta-analyses of RCTs of drugs versus active ingredient placebo, standard care, or psychotherapy. Sample populations were required to meet Diagnostic and Statistical Manual of Mental Disorders or International Classification of Diseases and Related Health Problems diagnostic criteria for anxiety disorders. Two reviewers independently searched EMBASE, EBM Reviews, Ovid MEDLINE, Ovid HealthSTAR, and International Pharmaceutical Abstracts from inception to August 2007. Search terms included meta-analysis, randomized controlled trials, anxiety, anxiolytic, anti-depressant/antidepressant, and pharmacotherapy, without language restrictions. References and reviews were searched manually. Quality was assessed independently by 2 raters, using the Quality of Reporting of Meta-analyses (QUOROM) and the Overview Quality Assessment Questionnaire (OQAQ). The QUOROM was used to assess the reporting quality of the study, using an 18-item che...Continue Reading

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Citations

Jul 29, 2009·Current Psychiatry Reports·Jonathan C Ipser, Dan J Stein
Oct 19, 2010·Preventive Veterinary Medicine·Annette O'Connor
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