Assessing the response of morphea and limited scleroderma to tranilast: a small prospective study comparing topical corticosteroids to a combination of topical corticosteroids and tranilast

Clinical, Cosmetic and Investigational Dermatology
Rowland Noakes

Abstract

Scleroderma is traditionally managed with immunomodulatory agents such as methotrexate, mycophenolate mofetil and corticosteroids. There are anecdotal reports for, and theoretical reasons why, the anti-fibrotic agent tranilast may provide an additional treatment modality. The objective of the current study was to demonstrate if the addition of topical tranilast to an established regime resulted in an improvement in the Localized Scleroderma Assessment Tool (LoSCAT) and modified Rodnan score. A small double-blinded randomized prospective study of 11 pairs of treatment sites in four patients; three with morphea and one with limited scleroderma was performed. All patients continued with their prescribed treatment and applied 0.1% betamethasone valerate in PCCA PracaSil™ (B) to the control site with 0.1% betamethasone valerate and 1% tranilast (B/T) to the comparator site over a period of 3 months. Photographs and monthly LoSCAT scores were performed on the morphea patients and a modified Rodnan score on the limited scleroderma patient. Statistical analysis was via sign test. The mean baseline LoScat score at the B treated sites was 6.6 which improved to 4.3 (p= 0.16). The mean baseline LoScat score at the B/T treated sites was 5.7...Continue Reading

Citations

Jun 4, 2019·Current Opinion in Pediatrics·Adriana G Peña-Romero, Maria T García-Romero
Jul 17, 2019·The Cochrane Database of Systematic Reviews·Julia V de AlbuquerqueVirginia Fm Trevisani
Dec 2, 2019·World Journal of Pediatrics : WJP·Suzanne C Li, Rong-Jun Zheng
May 11, 2021·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Yo Han Oh, Soo Hyang Lee

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Software Mentioned

LoScat
Localized Scleroderma Assessment Tool ( LoScat )
MS Excel

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