Assessing the Role and Optimal Duration of Hormonal Treatment in Association with Salvage Radiation Therapy After Radical Prostatectomy: Results from a Multi-Institutional Study

European Urology
Nicola FossatiAlberto Briganti

Abstract

The optimal duration of hormonal therapy (HT) when associated with postprostatectomy radiation therapy (RT) remains controversial. To test the impact of HT duration among patients treated with postprostatectomy RT, stratified by clinical and pathologic characteristics. The study included 1264 patients who received salvage RT (SRT) to the prostatic and seminal vesicle bed at eight referral centers after radical prostatectomy (RP). Patients received SRT for either rising prostate-specific antigen (PSA) or PSA persistence after RP, defined as PSA ≥0.1ng/ml at 1mo after surgery. Administration of concomitant HT was at the discretion of the treating physician. The outcome of interest was clinical recurrence (CR) after SRT, as identified by imaging. Multivariable Cox regression analysis was used to test the association between CR and HT duration. We applied an interaction test between HT duration and baseline risk factors to assess the hypothesis that CR-free survival differed by HT duration according to patient profile. Three risk factors were prespecified for evaluation: pT stage ≥pT3b, pathologic Gleason ≥8, and PSA level at SRT >0.5 ng/ml. The relationship between HT duration and CR-free survival rate at 8yr was graphically explo...Continue Reading

Citations

Nov 24, 2020·Expert Review of Anticancer Therapy·Lisa MorisSteven Joniau
Sep 14, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Detlef BartkowiakThomas Wiegel
Mar 4, 2021·Diagnostics·Giorgio NapodanoRoberto Sanseverino
Jul 27, 2021·Frontiers in Surgery·Fabio ZattoniGiorgio Gandaglia

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