Assessing the roles of endogenous retrovirus EAV-HP in avian leukosis virus subgroup J emergence and tolerance

Journal of Virology
Melanie A SaccoVenugopal K Nair

Abstract

Avian leukosis virus (ALV) subgroup J is thought to have emerged through a recombination event between an unknown exogenous ALV and the endogenous retrovirus elements designated EAV-HP. All EAV-HP elements identified to date in the chicken genome show large deletions, including that of the entire pol gene. Here we report the identification of four segregating chicken EAV-HP proviruses with complete pol genes, one of which shows exceptionally high sequence identity and a close phylogenetic relationship with ALV-J with respect to the env gene. Embryonic expression of EAV-HP env has been suggested as a factor associated with immunological tolerance induction in a proportion of ALV-J-infected meat-type chickens. In support of this, env gene transcripts expressed from two of the four newly identified EAV-HP proviruses were demonstrated in chicken embryos. However, when ALV-J-infected outbred meat-type chickens were assessed, the presence of intact EAV-HP proviruses failed to directly correlate with ALV-J tolerance. This association was further examined using F(2) progeny of two inbred lines of layer chicken that differed in EAV-HP status and immunological responses to ALV-J. Immunological tolerance developed in a small proportion of...Continue Reading

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Citations

Aug 31, 2013·PloS One·David WraggOlivier Hanotte
Aug 21, 2012·Trends in Ecology & Evolution·Amr Aswad, Aris Katzourakis
Mar 3, 2007·Molecular and Cellular Probes·Ravi TandonRegina Hofmann-Lehmann
Oct 16, 2015·BMC Genomics·David WraggOlivier Hanotte
Jun 7, 2014·The Journal of General Virology·Melanie Ann Sacco, Venugopal K Nair
Oct 18, 2005·The Journal of General Virology·Susan J BaigentVenugopal K Nair
Jan 10, 2020·The Journal of General Virology·Melanie Ann Sacco, Anna Crosetti
Nov 9, 2016·Frontiers in Cellular and Infection Microbiology·Min FengXiquan Zhang
Aug 9, 2006·The Journal of General Virology·Peter M ChestersVenugopal Nair
Dec 9, 2020·Annual Review of Animal Biosciences·Elliott S Chiu, Sue VandeWoude

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